Identification and characterization of the wbpO gene essential for lipopolysaccharide synthesis in Vibrio vulnificus

Na Young Park; Jeong Hyun Lee; Byung Cheol Lee; Tae Sung Kim; Sang Ho Choi

Identification and characterization of the wbpO gene essential for lipopolysaccharide synthesis in Vibrio vulnificus

Na Young Park, Jeong Hyun Lee, Byung Cheol Lee, Tae Sung Kim, Sang Ho Choi

Research output: Contribution to journal › Article › peer-review

Abstract

A wbpO gene encoding a putative UDP-N-acetyl-D-galactosamine dehydrogenase was identified and cloned from Vibrio vulnificus. LPS production was altered by disruption of the wbpO gene through allelic exchanges. The function of the wbpO gene in virulence assessed in vitro and in mice revealed that WbpO is important in both the pathogenesis of V. vulnificus and the biosynthesis of LPS.

Original language	English
Pages (from-to)	808-816
Number of pages	9
Journal	Journal of microbiology and biotechnology
Volume	16
Issue number	5
Publication status	Published - 2006 May

Keywords

LPS
Pathogenesis
V. vulnificus wbpO

ASJC Scopus subject areas

Biotechnology
Applied Microbiology and Biotechnology

Cite this

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title = "Identification and characterization of the wbpO gene essential for lipopolysaccharide synthesis in Vibrio vulnificus",

abstract = "A wbpO gene encoding a putative UDP-N-acetyl-D-galactosamine dehydrogenase was identified and cloned from Vibrio vulnificus. LPS production was altered by disruption of the wbpO gene through allelic exchanges. The function of the wbpO gene in virulence assessed in vitro and in mice revealed that WbpO is important in both the pathogenesis of V. vulnificus and the biosynthesis of LPS.",

keywords = "LPS, Pathogenesis, V. vulnificus wbpO",

author = "Park, {Na Young} and Lee, {Jeong Hyun} and Lee, {Byung Cheol} and Kim, {Tae Sung} and Choi, {Sang Ho}",

year = "2006",

month = may,

language = "English",

volume = "16",

pages = "808--816",

journal = "Journal of microbiology and biotechnology",

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T1 - Identification and characterization of the wbpO gene essential for lipopolysaccharide synthesis in Vibrio vulnificus

AU - Park, Na Young

AU - Lee, Jeong Hyun

AU - Lee, Byung Cheol

AU - Kim, Tae Sung

AU - Choi, Sang Ho

PY - 2006/5

Y1 - 2006/5

N2 - A wbpO gene encoding a putative UDP-N-acetyl-D-galactosamine dehydrogenase was identified and cloned from Vibrio vulnificus. LPS production was altered by disruption of the wbpO gene through allelic exchanges. The function of the wbpO gene in virulence assessed in vitro and in mice revealed that WbpO is important in both the pathogenesis of V. vulnificus and the biosynthesis of LPS.

AB - A wbpO gene encoding a putative UDP-N-acetyl-D-galactosamine dehydrogenase was identified and cloned from Vibrio vulnificus. LPS production was altered by disruption of the wbpO gene through allelic exchanges. The function of the wbpO gene in virulence assessed in vitro and in mice revealed that WbpO is important in both the pathogenesis of V. vulnificus and the biosynthesis of LPS.

KW - LPS

KW - Pathogenesis

KW - V. vulnificus wbpO

UR - http://www.scopus.com/inward/record.url?scp=33744963893&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33744963893

SN - 1017-7825

VL - 16

SP - 808

EP - 816

JO - Journal of microbiology and biotechnology

JF - Journal of microbiology and biotechnology

IS - 5

ER -

Identification and characterization of the wbpO gene essential for lipopolysaccharide synthesis in Vibrio vulnificus

Abstract

Keywords

ASJC Scopus subject areas

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