Keyphrases
Metabolism
100%
Loperamide
100%
Human Liver Microsomes
100%
Cytochrome P450 Isoforms
100%
N-methylation
46%
CYP2C8
46%
Cytochrome P450 2D6 (CYP2D6)
38%
Cytochrome P450 3A4 (CYP3A4)
30%
Complementary DNA (cDNA)
23%
Hydroxylation
15%
P450
15%
CYP3A4 Inhibition
15%
Low Affinity
7%
High Affinity
7%
Midazolam
7%
Enzyme Activity
7%
Paclitaxel
7%
Selective Inhibitor
7%
Demethylation
7%
Cytochrome P450 (CYP450)
7%
Chemical Inhibitors
7%
Quercetin
7%
Relative Contribution
7%
Clinical Significance
7%
Potential Interaction
7%
Formation Rate
7%
Factor Value
7%
Vmax
7%
Drug Interactions
7%
Enzyme Inhibition
7%
Therapeutic Concentrations
7%
Ketoconazole
7%
Biphasic Kinetics
7%
Relative Activity Factor
7%
P450 Activity
7%
Cytochrome P450 Inhibitors
7%
Pharmacology, Toxicology and Pharmaceutical Science
Cytochrome P450
100%
Loperamide
100%
CYP3A4
46%
CYP2C8
38%
Complementary DNA
23%
CYP2B6
23%
CYP2D6
15%
Midazolam
7%
Paclitaxel
7%
Quercetin
7%
Drug Interaction
7%
Ketoconazole
7%
Cytochrome P450 2C8 Inhibitor
7%
Biochemistry, Genetics and Molecular Biology