Identification of MCI individuals using structural and functional connectivity networks

Chong Yaw Wee, Pew Thian Yap, Daoqiang Zhang, Kevin Denny, Jeffrey N. Browndyke, Guy G. Potter, Kathleen A. Welsh-Bohmer, Lihong Wang, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

312 Citations (Scopus)


Different imaging modalities provide essential complementary information that can be used to enhance our understanding of brain disorders. This study focuses on integrating multiple imaging modalities to identify individuals at risk for mild cognitive impairment (MCI). MCI, often an early stage of Alzheimer's disease (AD), is difficult to diagnose due to its very mild or insignificant symptoms of cognitive impairment. Recent emergence of brain network analysis has made characterization of neurological disorders at a whole-brain connectivity level possible, thus providing new avenues for brain diseases classification. Employing multiple-kernel Support Vector Machines (SVMs), we attempt to integrate information from diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI) for improving classification performance. Our results indicate that the multimodality classification approach yields statistically significant improvement in accuracy over using each modality independently. The classification accuracy obtained by the proposed method is 96.3%, which is an increase of at least 7.4% from the single modality-based methods and the direct data fusion method. A cross-validation estimation of the generalization performance gives an area of 0.953 under the receiver operating characteristic (ROC) curve, indicating excellent diagnostic power. The multimodality classification approach hence allows more accurate early detection of brain abnormalities with greater sensitivity.

Original languageEnglish
Pages (from-to)2045-2056
Number of pages12
Issue number3
Publication statusPublished - 2012 Feb 1


  • Alzheimer's disease (AD)
  • Brain network analysis multiple-kernel Support Vector Machines (SVMs)
  • Diffusion tensor imaging (DTI)
  • Mild cognitive impairment (MCI)
  • Multimodality representation
  • Resting-state functional magnetic resonance imaging (rs-fMRI)

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


Dive into the research topics of 'Identification of MCI individuals using structural and functional connectivity networks'. Together they form a unique fingerprint.

Cite this