Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma

Keyphrases

• Colorectal Adenocarcinoma 100%
• DNA Hypermethylation 100%
• Adenylate Kinase 5 100%
• MRNA Expression 16%
• Colorectal Cancer 16%
• Colorectal Cancer Cell Lines 16%
• Hypermethylated 16%
• Cell-to-cell 8%
• Promoter Activity 8%
• Hypermethylation 8%
• DNA Methylation (DNAm) 8%
• Methylation 8%
• DNA Methyltransferase 1 (DNMT1) 8%
• Phosphorylation 8%
• Mammalian Target of Rapamycin (mTOR) 8%
• 5-azacytidine 8%
• DNA Methyltransferase Inhibitor 8%
• Cell Migration 8%
• Inverse Correlation 8%
• Metastasis 8%
• Cell Invasion 8%
• Kinase Family 8%
• Signaling Mechanism 8%
• 5-aza-2′-deoxycytidine 8%
• Non-tumor Tissue 8%
• Adenylate Kinase 8%
• Migration Invasion 8%
• Poor Differentiation 8%
• Gene Downregulation 8%
• Colorectal Tissue 8%
• AMPK-mTOR 8%
• Adenine nucleotides 8%
• Phosphorylated AMPK 8%
• Phosphate Transfer 8%

Biochemistry, Genetics and Molecular Biology

• Promoter Region 100%
• DNA Methylation 100%
• Adenylate Kinase 100%
• DNA Methyltransferase 15%
• Cancer Cell 15%
• AMP-activated Protein Kinase 15%
• Messenger RNA 15%
• Methylation 7%
• Downregulation 7%
• Cell Migration 7%
• Cell Invasion 7%
• Mammalian Target of Rapamycin 7%
• Signaling Mechanism 7%
• Adenine 7%
• Decitabine 7%
• mTOR Signaling 7%
• Energy Transfer 7%

Pharmacology, Toxicology and Pharmaceutical Science

• Colorectal Carcinoma 100%
• Adenylate Kinase 100%
• Messenger RNA 15%
• DNA Methyltransferase 7%
• Decitabine 7%
• DNA Methyltransferase Inhibitor 7%
• Adenine Nucleotide 7%