Identification of novel electroconvulsive shock-induced and activity-dependent genes in the rat brain

Woong Sun; Kun Woo Park; Jeehyung Choe; Im Joo Rhyu; Il Hwan Kim; Soon Kwon Park; Byungil Choi; Sang Hyun Choi; Sun Hwa Park; Hyun Kim

doi:10.1016/j.bbrc.2004.12.050

Identification of novel electroconvulsive shock-induced and activity-dependent genes in the rat brain

Woong Sun
, Kun Woo Park
, Jeehyung Choe
, Im Joo Rhyu
, Il Hwan Kim
, Soon Kwon Park
, Byungil Choi
, Sang Hyun Choi
, Sun Hwa Park
, Hyun Kim

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Electroconvulsive shock (ECS) has been used as an effective treatment for patients suffering from major depression disorders and schizophrenia. However, the exact mechanisms underlying the action of ECS are poorly understood. Using high-density oligonucleotide microarrays, we identified 60 ECS-induced genes whose gene products are involved in the neuronal signaling, neuritogenesis and tissue remodeling. In situ hybridization and depolarization-dependent expression assay were performed to characterize 4 genes (lysyl oxidase, Ab1-046, SOX11, and T-type calcium channel 1G subunit) which have not yet been reported to be induced by ECS. Interestingly, the induction of these genes was observed mainly in the dentate gyrus of hippocampal formation and piriform cortex, where ECS-induced neural activation is highlighted, and depolarization of cultured cortical neurons also induced the expression of these genes. Taken together, our results suggest that therapeutic actions of ECS may be manifested by the activity-dependent induction of genes related to the plastic changes of the brain such as neuronal signaling neuritogenesis, and tissue remodeling.

Original language	English
Pages (from-to)	848-856
Number of pages	9
Journal	Biochemical and biophysical research communications
Volume	327
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2004.12.050
Publication status	Published - 2005 Feb 18
Externally published	Yes

Bibliographical note

Funding Information:
We thank Dr. Sangduk Kim for valuable comments on the manuscript and to Seoulin Bioscience Co., for the technical assistance. This work was supported by grant of the Korean Health 21 R&D Project, Korean Ministry of Health and Welfare (HMP-00-GN-01-0002). A part of this work is technically supported by a core facility service of 21C frontier Brain Research Center.

Keywords

Electroconvulsive shock
Microarray
Neural activity
Tissue remodeling

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2004.12.050

Cite this

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title = "Identification of novel electroconvulsive shock-induced and activity-dependent genes in the rat brain",

abstract = "Electroconvulsive shock (ECS) has been used as an effective treatment for patients suffering from major depression disorders and schizophrenia. However, the exact mechanisms underlying the action of ECS are poorly understood. Using high-density oligonucleotide microarrays, we identified 60 ECS-induced genes whose gene products are involved in the neuronal signaling, neuritogenesis and tissue remodeling. In situ hybridization and depolarization-dependent expression assay were performed to characterize 4 genes (lysyl oxidase, Ab1-046, SOX11, and T-type calcium channel 1G subunit) which have not yet been reported to be induced by ECS. Interestingly, the induction of these genes was observed mainly in the dentate gyrus of hippocampal formation and piriform cortex, where ECS-induced neural activation is highlighted, and depolarization of cultured cortical neurons also induced the expression of these genes. Taken together, our results suggest that therapeutic actions of ECS may be manifested by the activity-dependent induction of genes related to the plastic changes of the brain such as neuronal signaling neuritogenesis, and tissue remodeling.",

keywords = "Electroconvulsive shock, Microarray, Neural activity, Tissue remodeling",

author = "Woong Sun and Park, \{Kun Woo\} and Jeehyung Choe and Rhyu, \{Im Joo\} and Kim, \{Il Hwan\} and Park, \{Soon Kwon\} and Byungil Choi and Choi, \{Sang Hyun\} and Park, \{Sun Hwa\} and Hyun Kim",

note = "Funding Information: We thank Dr. Sangduk Kim for valuable comments on the manuscript and to Seoulin Bioscience Co., for the technical assistance. This work was supported by grant of the Korean Health 21 R\&D Project, Korean Ministry of Health and Welfare (HMP-00-GN-01-0002). A part of this work is technically supported by a core facility service of 21C frontier Brain Research Center.",

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AU - Sun, Woong

AU - Park, Kun Woo

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AU - Kim, Il Hwan

AU - Park, Soon Kwon

AU - Choi, Byungil

AU - Choi, Sang Hyun

AU - Park, Sun Hwa

AU - Kim, Hyun

N1 - Funding Information: We thank Dr. Sangduk Kim for valuable comments on the manuscript and to Seoulin Bioscience Co., for the technical assistance. This work was supported by grant of the Korean Health 21 R&D Project, Korean Ministry of Health and Welfare (HMP-00-GN-01-0002). A part of this work is technically supported by a core facility service of 21C frontier Brain Research Center.

PY - 2005/2/18

Y1 - 2005/2/18

N2 - Electroconvulsive shock (ECS) has been used as an effective treatment for patients suffering from major depression disorders and schizophrenia. However, the exact mechanisms underlying the action of ECS are poorly understood. Using high-density oligonucleotide microarrays, we identified 60 ECS-induced genes whose gene products are involved in the neuronal signaling, neuritogenesis and tissue remodeling. In situ hybridization and depolarization-dependent expression assay were performed to characterize 4 genes (lysyl oxidase, Ab1-046, SOX11, and T-type calcium channel 1G subunit) which have not yet been reported to be induced by ECS. Interestingly, the induction of these genes was observed mainly in the dentate gyrus of hippocampal formation and piriform cortex, where ECS-induced neural activation is highlighted, and depolarization of cultured cortical neurons also induced the expression of these genes. Taken together, our results suggest that therapeutic actions of ECS may be manifested by the activity-dependent induction of genes related to the plastic changes of the brain such as neuronal signaling neuritogenesis, and tissue remodeling.

AB - Electroconvulsive shock (ECS) has been used as an effective treatment for patients suffering from major depression disorders and schizophrenia. However, the exact mechanisms underlying the action of ECS are poorly understood. Using high-density oligonucleotide microarrays, we identified 60 ECS-induced genes whose gene products are involved in the neuronal signaling, neuritogenesis and tissue remodeling. In situ hybridization and depolarization-dependent expression assay were performed to characterize 4 genes (lysyl oxidase, Ab1-046, SOX11, and T-type calcium channel 1G subunit) which have not yet been reported to be induced by ECS. Interestingly, the induction of these genes was observed mainly in the dentate gyrus of hippocampal formation and piriform cortex, where ECS-induced neural activation is highlighted, and depolarization of cultured cortical neurons also induced the expression of these genes. Taken together, our results suggest that therapeutic actions of ECS may be manifested by the activity-dependent induction of genes related to the plastic changes of the brain such as neuronal signaling neuritogenesis, and tissue remodeling.

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KW - Microarray

KW - Neural activity

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Identification of novel electroconvulsive shock-induced and activity-dependent genes in the rat brain

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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