Identification of the antidepressant function of the edible mushroom Pleurotus eryngii

Yong Sung Park, Subin Jang, Hyunkoo Lee, Suzie Kang, Hyewon Seo, Seoyeong Yeon, Dongho Lee, Cheol Won Yun

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Pleurotus eryngii produces various functional molecules that mediate physiological functions in humans. Recently, we observed that P. eryngii produces molecules that have antidepressant functions. An ethanol extract of the fruiting body of P. eryngii was obtained, and the extract was purified by XAD-16 resin using an open column system. The ethanol eluate was separated by HPLC, and the fraction with an antidepressant function was identified. Using LC-MS, the molecular structure of the HPLC fraction with antidepressant function was identified as that of tryptamine, a functional molecule that is a tryptophan derivative. The antidepressant effect was identified from the ethanol extract, XAD-16 column eluate, and HPLC fraction by a serotonin receptor binding assay and a cell-based binding assay. Furthermore, a forced swimming test (FST) showed that the mice treated with purified fractions of P. eryngii exhibited decreased immobility time compared with nontreated mice. From these results, we suggest that the extract of P. eryngii has an antidepressant function and that it may be employed as an antidepressant health supplement.

Original languageEnglish
Article number190
JournalJournal of Fungi
Issue number3
Publication statusPublished - 2021 Mar

Bibliographical note

Funding Information:
Acknowledgments: This work was carried out with the support of the Cooperative Research Program for Agriculture Science and Technology Development (Project No: PJ01368101), Rural Development Administration, Republic of Korea.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Antidepressants
  • Fungi
  • Mushrooms
  • P. eryngii
  • Tryptamine

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Plant Science
  • Microbiology (medical)


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