IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β signaling

Suk Jun Lee; Eun Ju Lee; Sang Hoon Kim; Inho Choi; Dong Mok Lee; Hyun Jeong Lee; Duhak Yoon; Taehoon Chun

doi:10.1007/s10529-010-0440-4

IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β signaling

Suk Jun Lee, Eun Ju Lee, Sang Hoon Kim, Inho Choi, Dong Mok Lee, Hyun Jeong Lee, Duhak Yoon, Taehoon Chun

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Purpose of work: Helper 17 T (Th17) effector cells are a recently identified Th subset and possess a unique property that distinguishes them from Th1 and Th2 subsets. The functional role of Th17 effector cells involves inflammatory responses, including autoimmunity and infection of specific pathogens. Therefore, IL-17A and its receptors may play a key role in determining the progression of certain inflammatory reactions. However, the relationship between IL-17A and adipogenesis has not yet been examined. Therefore, in this study, the effect of IL-17A on the adipogenic transdifferentiation of mouse myoblast (C2C12) cells was examined. CAAT/enhancer binding-protein β (C/EPBβ) signaling through the IL-17A receptor promoted adipogenic transdifferentiation of myoblast cells by activating peroxisome proliferator-activated receptor γ (PPARγ). These results will advance our understanding of the physiological function of IL-17A in myoblasts during inflammation, as well as the relationship between adipogenesis and inflammation.

Original language	English
Pages (from-to)	229-235
Number of pages	7
Journal	Biotechnology letters
Volume	33
Issue number	2
DOIs	https://doi.org/10.1007/s10529-010-0440-4
Publication status	Published - 2011 Feb

Bibliographical note

Funding Information:
Acknowledgments This study was supported by the Technology Development Program for Agriculture and Forestry, Ministry for Agriculture, Forestry and Fisheries, Republic of Korea.

Keywords

Adipocyte
IL-17A
Inflammation
Myoblast
Transdifferentiation

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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Lee, S. J., Lee, E. J., Kim, S. H., Choi, I., Lee, D. M., Lee, H. J., Yoon, D., & Chun, T. (2011). IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β signaling. Biotechnology letters, 33(2), 229-235. https://doi.org/10.1007/s10529-010-0440-4

IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β signaling. / Lee, Suk Jun; Lee, Eun Ju; Kim, Sang Hoon et al.
In: Biotechnology letters, Vol. 33, No. 2, 02.2011, p. 229-235.

Research output: Contribution to journal › Article › peer-review

Lee, SJ, Lee, EJ, Kim, SH, Choi, I, Lee, DM, Lee, HJ, Yoon, D & Chun, T 2011, 'IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β signaling', Biotechnology letters, vol. 33, no. 2, pp. 229-235. https://doi.org/10.1007/s10529-010-0440-4

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abstract = "Purpose of work: Helper 17 T (Th17) effector cells are a recently identified Th subset and possess a unique property that distinguishes them from Th1 and Th2 subsets. The functional role of Th17 effector cells involves inflammatory responses, including autoimmunity and infection of specific pathogens. Therefore, IL-17A and its receptors may play a key role in determining the progression of certain inflammatory reactions. However, the relationship between IL-17A and adipogenesis has not yet been examined. Therefore, in this study, the effect of IL-17A on the adipogenic transdifferentiation of mouse myoblast (C2C12) cells was examined. CAAT/enhancer binding-protein β (C/EPBβ) signaling through the IL-17A receptor promoted adipogenic transdifferentiation of myoblast cells by activating peroxisome proliferator-activated receptor γ (PPARγ). These results will advance our understanding of the physiological function of IL-17A in myoblasts during inflammation, as well as the relationship between adipogenesis and inflammation.",

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IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β signaling

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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