IL-18 gene expression pattern in exogenously treated AML cells

Minji Seo; Minha Park; Yeonjoo Yook; Sook Kwon Young; Ju Suh Young; Jung Kim Min; Daeho Cho; Hoon Park Jong

doi:10.5483/bmbrep.2008.41.6.461

IL-18 gene expression pattern in exogenously treated AML cells

Minji Seo, Minha Park, Yeonjoo Yook, Sook Kwon Young, Ju Suh Young, Jung Kim Min, Daeho Cho, Hoon Park Jong

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expression of 57 genes, including stress related genes, increased at least 2-fold, whereas expression of 48 genes decreased at least 2-fold. Following exogenous exposure of KG-1 cells to IL-18, expression of CRYGC, NFκBIA and NACA gene were monitored. The latter is a transcriptional coactivator potentiating c-Jun-mediated transcription. NFκBIA is an inhibitor of NFκB, and affects growth regulation, apoptosis and hypoxic stress. Studies, such as this one, are beginning to clarify the differences between cells associated with good and bad cancer prognoses, which may ultimately assist in medical treatment for acute myeloid leukemia.

Original language	English
Pages (from-to)	461-465
Number of pages	5
Journal	Journal of Biochemistry and Molecular Biology
Volume	41
Issue number	6
DOIs	https://doi.org/10.5483/bmbrep.2008.41.6.461
Publication status	Published - 2008 Jun
Externally published	Yes

Keywords

IL-18
KG-1
Microarray
Prognosis

ASJC Scopus subject areas

Biochemistry
Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5483/bmbrep.2008.41.6.461

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title = "IL-18 gene expression pattern in exogenously treated AML cells",

abstract = "IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expression of 57 genes, including stress related genes, increased at least 2-fold, whereas expression of 48 genes decreased at least 2-fold. Following exogenous exposure of KG-1 cells to IL-18, expression of CRYGC, NFκBIA and NACA gene were monitored. The latter is a transcriptional coactivator potentiating c-Jun-mediated transcription. NFκBIA is an inhibitor of NFκB, and affects growth regulation, apoptosis and hypoxic stress. Studies, such as this one, are beginning to clarify the differences between cells associated with good and bad cancer prognoses, which may ultimately assist in medical treatment for acute myeloid leukemia.",

keywords = "IL-18, KG-1, Microarray, Prognosis",

author = "Minji Seo and Minha Park and Yeonjoo Yook and Young, {Sook Kwon} and Young, {Ju Suh} and Min, {Jung Kim} and Daeho Cho and Jong, {Hoon Park}",

year = "2008",

month = jun,

doi = "10.5483/bmbrep.2008.41.6.461",

language = "English",

volume = "41",

pages = "461--465",

journal = "Journal of Biochemistry and Molecular Biology",

issn = "1225-8687",

publisher = "The Biochemical Society of the Republic of Korea",

number = "6",

}

TY - JOUR

T1 - IL-18 gene expression pattern in exogenously treated AML cells

AU - Seo, Minji

AU - Park, Minha

AU - Yook, Yeonjoo

AU - Young, Sook Kwon

AU - Young, Ju Suh

AU - Min, Jung Kim

AU - Cho, Daeho

AU - Jong, Hoon Park

PY - 2008/6

Y1 - 2008/6

N2 - IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expression of 57 genes, including stress related genes, increased at least 2-fold, whereas expression of 48 genes decreased at least 2-fold. Following exogenous exposure of KG-1 cells to IL-18, expression of CRYGC, NFκBIA and NACA gene were monitored. The latter is a transcriptional coactivator potentiating c-Jun-mediated transcription. NFκBIA is an inhibitor of NFκB, and affects growth regulation, apoptosis and hypoxic stress. Studies, such as this one, are beginning to clarify the differences between cells associated with good and bad cancer prognoses, which may ultimately assist in medical treatment for acute myeloid leukemia.

AB - IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expression of 57 genes, including stress related genes, increased at least 2-fold, whereas expression of 48 genes decreased at least 2-fold. Following exogenous exposure of KG-1 cells to IL-18, expression of CRYGC, NFκBIA and NACA gene were monitored. The latter is a transcriptional coactivator potentiating c-Jun-mediated transcription. NFκBIA is an inhibitor of NFκB, and affects growth regulation, apoptosis and hypoxic stress. Studies, such as this one, are beginning to clarify the differences between cells associated with good and bad cancer prognoses, which may ultimately assist in medical treatment for acute myeloid leukemia.

KW - IL-18

KW - KG-1

KW - Microarray

KW - Prognosis

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U2 - 10.5483/bmbrep.2008.41.6.461

DO - 10.5483/bmbrep.2008.41.6.461

M3 - Article

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AN - SCOPUS:46249105544

SN - 1225-8687

VL - 41

SP - 461

EP - 465

JO - Journal of Biochemistry and Molecular Biology

JF - Journal of Biochemistry and Molecular Biology

IS - 6

ER -

IL-18 gene expression pattern in exogenously treated AML cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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