IL-18 gene expression pattern in exogenously treated AML cells

Minji Seo, Minha Park, Yeonjoo Yook, Sook Kwon Young, Ju Suh Young, Jung Kim Min, Daeho Cho, Hoon Park Jong

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


IL-18 production may enhance immune system defense against KG-1 cells ; NB4 cells, which are associated with good prognosis, do not produce IL-18. In this study, we treated KG-1 cells with IL-18 and used microarray technology to assess subsequent effects on gene expression. In UniGene-array of 7488 human genes, expression of 57 genes, including stress related genes, increased at least 2-fold, whereas expression of 48 genes decreased at least 2-fold. Following exogenous exposure of KG-1 cells to IL-18, expression of CRYGC, NFκBIA and NACA gene were monitored. The latter is a transcriptional coactivator potentiating c-Jun-mediated transcription. NFκBIA is an inhibitor of NFκB, and affects growth regulation, apoptosis and hypoxic stress. Studies, such as this one, are beginning to clarify the differences between cells associated with good and bad cancer prognoses, which may ultimately assist in medical treatment for acute myeloid leukemia.

Original languageEnglish
Pages (from-to)461-465
Number of pages5
JournalJournal of Biochemistry and Molecular Biology
Issue number6
Publication statusPublished - 2008 Jun
Externally publishedYes


  • IL-18
  • KG-1
  • Microarray
  • Prognosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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