"Illusionary" Polymerase activity triggered by metal ions: Use for molecular logic-gate operations

Ki Soo Park; Cheulhee Jung; Hyun Gyu Park

doi:10.1002/anie.201004406

"Illusionary" Polymerase activity triggered by metal ions: Use for molecular logic-gate operations

Ki Soo Park, Cheulhee Jung, Hyun Gyu Park

Research output: Contribution to journal › Article › peer-review

147 Citations (Scopus)

Abstract

Metal ion, an astonishing illusionist: In a new concept, "illusionary" polymerase activity is intentionally triggered at T-T and C-C mismatched primers by Hg²⁺ and Ag⁺ ions, respectively. A novel strategy to construct molecular-scale logic gates utilizes the nonnatural polymerase activity induced by the metal ions by rational design of the primers and selection of the type of DNA polymerase (see picture).

Original language	English
Pages (from-to)	9757-9760
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	50
DOIs	https://doi.org/10.1002/anie.201004406
Publication status	Published - 2010 Dec 10
Externally published	Yes

Keywords

DNA
mercury
molecular logic gates
nucleotides
silver

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201004406

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KW - silver

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"Illusionary" Polymerase activity triggered by metal ions: Use for molecular logic-gate operations

Abstract

Keywords

ASJC Scopus subject areas

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