Immunogenicity and safety of influenza A (H1N1) 2009 monovalent inactivated split vaccine in Korea

Hee Jin Cheong, Joon Young Song, Jung Yeon Heo, Ji Yun Noh, Won Suk Choi, Dae Won Park, Seong Heon Wie, Woo Joo Kim

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)


    In a pandemic, the development of an effective influenza vaccine is the most important subject from the view of public health. This study was performed to evaluate the immunogenicity and safety of inactivated, monovalent H1N1 2009 vaccine (Green Cross Corporation, Yongin, Korea) among healthy adults aged 19-64 years (Group 1) and the elderly aged ≥65 years (Group 2) in a two-dose regimen, 21 days apart. At baseline, 28 of 454 participants (6.1%) had hemagglutination-inhibition titers of ≥1:40 with no significant difference between age groups (p=0.27). There was an apparent dose-dependent antibody response; participants receiving the dose of 30μg hemagglutinin (HA) showed higher geometric mean titers (GMTs) than the 15μg HA group in both age groups. Despite the rates of seroprotection and seroconversion were significantly higher with 30μg HA formulation than 15μg HA formula in Group 2, there was no definite difference in Group 1 irrespective of vaccine formula. Significant GMT elevation after the second dose was not noted in either age group, regardless vaccine formulations. No deaths, vaccine-related serious adverse events, or immediate unsolicited adverse reactions occurred during the study periods.

    Original languageEnglish
    Pages (from-to)523-527
    Number of pages5
    Issue number3
    Publication statusPublished - 2011 Jan 10


    • 2009 H1N1
    • Immunogenicity
    • Influenza
    • Vaccination

    ASJC Scopus subject areas

    • Molecular Medicine
    • Immunology and Microbiology(all)
    • veterinary(all)
    • Public Health, Environmental and Occupational Health
    • Infectious Diseases


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