Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University

Gang Jee Ko; Asif Zakaria; Karl L. Womer; Hamid Rabb

doi:10.1007/s12026-009-8140-7

Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University

Gang Jee Ko
, Asif Zakaria
, Karl L. Womer
, Hamid Rabb^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Abstracts: Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches.

Original language	English
Pages (from-to)	78-85
Number of pages	8
Journal	Immunologic Research
Volume	47
Issue number	1-3
DOIs	https://doi.org/10.1007/s12026-009-8140-7
Publication status	Published - 2010 Jul
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments This work was supported by the NIDDK, NHLBI, NKF, and AHA. We are grateful to the many trainees and staff who have contributed to the work summarized in this article.

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Keywords

Acute kidney injury
Inflammation
Ischemia/reperfusion injury

ASJC Scopus subject areas

Immunology

Access to Document

10.1007/s12026-009-8140-7

Cite this

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title = "Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University",

abstract = "Abstracts: Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches.",

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note = "Funding Information: Acknowledgments This work was supported by the NIDDK, NHLBI, NKF, and AHA. We are grateful to the many trainees and staff who have contributed to the work summarized in this article. Copyright: Copyright 2010 Elsevier B.V., All rights reserved.",

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doi = "10.1007/s12026-009-8140-7",

language = "English",

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AU - Ko, Gang Jee

AU - Zakaria, Asif

AU - Womer, Karl L.

AU - Rabb, Hamid

N1 - Funding Information: Acknowledgments This work was supported by the NIDDK, NHLBI, NKF, and AHA. We are grateful to the many trainees and staff who have contributed to the work summarized in this article. Copyright: Copyright 2010 Elsevier B.V., All rights reserved.

PY - 2010/7

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N2 - Abstracts: Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches.

AB - Abstracts: Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches.

KW - Acute kidney injury

KW - Inflammation

KW - Ischemia/reperfusion injury

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DO - 10.1007/s12026-009-8140-7

M3 - Review article

C2 - 20082154

AN - SCOPUS:77953957887

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EP - 85

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JF - Immunologic Research

IS - 1-3

ER -

Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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