Impact of early-life stress and resilience on patients with major depressive disorder

Jeong Ho Seok, Kyoung Uk Lee, Won Kim, Seung Hwan Lee, Eun Ho Kang, Byung Joo Ham, Jong Chul Yang, Jeong Ho Chae

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


Purpose: Early-life stress (ELS) has a long-lasting effect on affective function and may entail an increased risk for major depressive disorder (MDD). However, resilience can play a protective role against developing psychopathology. In this study, we investigated the relationships of depressive symptoms with ELS and resilience in MDD. Materials and Methods: Twenty-six patients with MDD as well as age- and gender-matched healthy controls were included in this study. Each subject was assessed concerning ELS, resilience, and depressive symptom severity with self-report questionnaires. Independent samples t-test and Mann-Whitney test were performed to compare ELS and resilience between the patient and control groups. Spearman correlation analyses and linear regression analysis were conducted to investigate significant ELS and resilience factors associated with depressive symptoms. Results: In the MDD patient group, subjects reported greater exposure to inter- parental violence, and five factor scores on the resilience scale were significantly lower in comparison to the control group. In linear regression analysis, in regards to resilience, depressive symptom score was significantly associated with self-confidence and self-control factors; however, ELS demonstrated no significant association with depressive symptoms. Conclusion: Among resilience factors, self-confidence and self-control may ameliorate depressive symptoms in MDD. ELS, including inter-parental violence, physical abuse and emotional abuse, might be a risk factor for developing depression. Assessment of early-life stress and intervention programs for increasing resilience capacity would be helpful in treating MDD.

Original languageEnglish
Pages (from-to)1093-1098
Number of pages6
JournalYonsei medical journal
Issue number6
Publication statusPublished - 2012 Nov


  • Depressive disorder
  • Inter-parental violence
  • Resilience
  • Self-confidence
  • Self-control

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Impact of early-life stress and resilience on patients with major depressive disorder'. Together they form a unique fingerprint.

Cite this