Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients

Jung Joon Cha; Jae Hyoung Park; Hyung Joon Joo; Soon Jun Hong; Tae Hoon Ahn; Byeong Keuk Kim; Won Yong Shin; Sung Gyun Ahn; Jung Han Yoon; Yong Hoon Kim; Yun Hyeong cho; Woong Chol Kang; Weon Kim; Young Hyo Lim; Hyeon Cheol Gwon; Woong Gil Choi; Do Sun Lim

doi:10.18632/aging.202799

Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients

Jung Joon Cha, Jae Hyoung Park, Hyung Joon Joo, Soon Jun Hong, Tae Hoon Ahn, Byeong Keuk Kim, Won Yong Shin, Sung Gyun Ahn, Jung Han Yoon, Yong Hoon Kim, Yun Hyeong cho, Woong Chol Kang, Weon Kim, Young Hyo Lim, Hyeon Cheol Gwon, Woong Gil Choi, Do Sun Lim

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Elderly patients treated with percutaneous coronary intervention (PCI) have a higher risk of both ischemic and bleeding complications than younger patients. However, few studies have reported how genetic information of elderly patients treated with PCI affects clinical outcomes. We investigated the impact of genetic variants on clinical outcomes in elderly patients. Correlations between single-nucleotide polymorphisms (CYP2C19 and P2Y12 receptor gene G52T polymorphism) and clinical outcomes were analyzed in 811 elderly patients (≥75 years of age) from a prospective multicenter registry. The primary endpoint was a composite of myocardial infarction and death.

Original language	English
Pages (from-to)	6506-6517
Number of pages	12
Journal	Aging
Volume	13
Issue number	5
DOIs	https://doi.org/10.18632/aging.202799
Publication status	Published - 2021 Mar 15
Externally published	Yes

Keywords

P2Y12 receptor gene polymorphism
clinical
coronary artery disease
cytochrome P-450 CYP2C19
elderly
outcome

ASJC Scopus subject areas

Ageing
Cell Biology

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10.18632/aging.202799

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Cha, J. J., Hyoung Park, J., Joo, H. J., Hong, S. J., Hoon Ahn, T., Kim, B. K., Shin, W. Y., Ahn, S. G., Yoon, J. H., Kim, Y. H., cho, Y. H., Kang, W. C., Kim, W., Lim, Y. H., Cheol Gwon, H., Gil Choi, W., & Lim, D. S. (2021). Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients. Aging, 13(5), 6506-6517. https://doi.org/10.18632/aging.202799

@article{15e8489101a9419a81813668e2ababb0,

title = "Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients",

abstract = "Elderly patients treated with percutaneous coronary intervention (PCI) have a higher risk of both ischemic and bleeding complications than younger patients. However, few studies have reported how genetic information of elderly patients treated with PCI affects clinical outcomes. We investigated the impact of genetic variants on clinical outcomes in elderly patients. Correlations between single-nucleotide polymorphisms (CYP2C19 and P2Y12 receptor gene G52T polymorphism) and clinical outcomes were analyzed in 811 elderly patients (≥75 years of age) from a prospective multicenter registry. The primary endpoint was a composite of myocardial infarction and death.",

keywords = "P2Y12 receptor gene polymorphism, clinical, coronary artery disease, cytochrome P-450 CYP2C19, elderly, outcome",

author = "Cha, {Jung Joon} and {Hyoung Park}, Jae and Joo, {Hyung Joon} and Hong, {Soon Jun} and {Hoon Ahn}, Tae and Kim, {Byeong Keuk} and Shin, {Won Yong} and Ahn, {Sung Gyun} and Yoon, {Jung Han} and Kim, {Yong Hoon} and cho, {Yun Hyeong} and Kang, {Woong Chol} and Weon Kim and Lim, {Young Hyo} and {Cheol Gwon}, Hyeon and {Gil Choi}, Woong and Lim, {Do Sun}",

note = "Funding Information: This work was supported by Dong-A ST Co., Ltd. All authors declare that the funders had no role in the study design, data collection and analysis, preparation of the manuscript, or decision to publish. Publisher Copyright: {\textcopyright} 2021 Cha et al. All rights reserved.",

year = "2021",

month = mar,

day = "15",

doi = "10.18632/aging.202799",

language = "English",

volume = "13",

pages = "6506--6517",

journal = "Aging",

issn = "0002-0966",

publisher = "US Administration on Aging",

number = "5",

}

TY - JOUR

T1 - Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients

AU - Cha, Jung Joon

AU - Hyoung Park, Jae

AU - Joo, Hyung Joon

AU - Hong, Soon Jun

AU - Hoon Ahn, Tae

AU - Kim, Byeong Keuk

AU - Shin, Won Yong

AU - Ahn, Sung Gyun

AU - Yoon, Jung Han

AU - Kim, Yong Hoon

AU - cho, Yun Hyeong

AU - Kang, Woong Chol

AU - Kim, Weon

AU - Lim, Young Hyo

AU - Cheol Gwon, Hyeon

AU - Gil Choi, Woong

AU - Lim, Do Sun

N1 - Funding Information: This work was supported by Dong-A ST Co., Ltd. All authors declare that the funders had no role in the study design, data collection and analysis, preparation of the manuscript, or decision to publish. Publisher Copyright: © 2021 Cha et al. All rights reserved.

PY - 2021/3/15

Y1 - 2021/3/15

N2 - Elderly patients treated with percutaneous coronary intervention (PCI) have a higher risk of both ischemic and bleeding complications than younger patients. However, few studies have reported how genetic information of elderly patients treated with PCI affects clinical outcomes. We investigated the impact of genetic variants on clinical outcomes in elderly patients. Correlations between single-nucleotide polymorphisms (CYP2C19 and P2Y12 receptor gene G52T polymorphism) and clinical outcomes were analyzed in 811 elderly patients (≥75 years of age) from a prospective multicenter registry. The primary endpoint was a composite of myocardial infarction and death.

AB - Elderly patients treated with percutaneous coronary intervention (PCI) have a higher risk of both ischemic and bleeding complications than younger patients. However, few studies have reported how genetic information of elderly patients treated with PCI affects clinical outcomes. We investigated the impact of genetic variants on clinical outcomes in elderly patients. Correlations between single-nucleotide polymorphisms (CYP2C19 and P2Y12 receptor gene G52T polymorphism) and clinical outcomes were analyzed in 811 elderly patients (≥75 years of age) from a prospective multicenter registry. The primary endpoint was a composite of myocardial infarction and death.

KW - P2Y12 receptor gene polymorphism

KW - clinical

KW - coronary artery disease

KW - cytochrome P-450 CYP2C19

KW - elderly

KW - outcome

UR - http://www.scopus.com/inward/record.url?scp=85102845409&partnerID=8YFLogxK

U2 - 10.18632/aging.202799

DO - 10.18632/aging.202799

M3 - Article

C2 - 33707344

AN - SCOPUS:85102845409

SN - 0002-0966

VL - 13

SP - 6506

EP - 6517

JO - Aging

JF - Aging

IS - 5

ER -

Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients

Abstract

Keywords

ASJC Scopus subject areas

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