Impact of non-alcoholic fatty liver disease on the risk of sarcopenia: a nationwide multicenter prospective study

Eun Roh; Soon Young Hwang; Hye Jin Yoo; Sei Hyun Baik; Jin Hee Lee; Sang Joon Son; Hyeon Ju Kim; Yong Soon Park; Sam Gyu Lee; Be Long Cho; Hak Chul Jang; Bong Jo Kim; Miji Kim; Chang Won Won; Kyung Mook Choi

doi:10.1007/s12072-021-10258-8

Impact of non-alcoholic fatty liver disease on the risk of sarcopenia: a nationwide multicenter prospective study

Eun Roh, Soon Young Hwang, Hye Jin Yoo, Sei Hyun Baik, Jin Hee Lee, Sang Joon Son, Hyeon Ju Kim, Yong Soon Park, Sam Gyu Lee, Be Long Cho, Hak Chul Jang, Bong Jo Kim, Miji Kim, Chang Won Won, Kyung Mook Choi

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Background and aims: Despite the association between sarcopenia and non-alcoholic fatty liver disease (NAFLD), no study has evaluated the predictive role of NAFLD in sarcopenia. We investigated impact of NAFLD on the risk of low muscle mass (LMM) and low muscle strength (LMS) in a nationwide multicenter study. Methods: A total of 1595 community-dwelling people aged 70–84 years were followed for 2 years in the Korean Frailty and Aging Cohort Study. Muscle mass was estimated by dividing appendicular skeletal muscle mass (ASM) by body mass index (BMI). Muscle strength was measured as handgrip strength (HGS) divided by BMI. The sex-specific lowest quintiles of ASM/BMI and HGS/BMI of the study population were used as cutoffs for LMM and LMS, respectively. The risk of LMM and LMS were assessed according to hepatic steatosis index (HSI) and fatty liver index (FLI) quartiles. Results: As HSI quartiles increased, the LMM risk increased gradually, after adjusting for age, sex, lifestyle factors, comorbidities, and several causative factors (insulin resistance, inflammation, and vitamin D) (Q4 vs. Q1 OR [95% CI] 3.46 [2.23–5.35]). The increased risk of LMS was even higher according to HSI quartiles (Q4 vs. Q1 5.81 [3.67–9.21]). Multivariate analyses based on FLI showed similar results. People with NAFLD (HSI > 36) were at higher risk of developing LMM and LMS compared to those without (1.65 [1.19–2.31] and 2.29 [1.61–3.26], respectively). Conclusions: The presence of NAFLD may predict future risk of LMM and LMS, with greater impact on LMS than on LMM. Graphic abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	545-554
Number of pages	10
Journal	Hepatology International
Volume	16
Issue number	3
DOIs	https://doi.org/10.1007/s12072-021-10258-8
Publication status	Published - 2022 Jun

Bibliographical note

Funding Information:
This study was supported by grant from the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare of Korea (grant number: HI15C3153) and grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Education of Korea (grant number: 2020R1I1A1A01070499) This work was also supported by Korea University Guro Hospital (Korea Research-Driven Hospital) and grant funded by Korea University Medicine (K2115701).

Publisher Copyright:
© 2021, Asian Pacific Association for the Study of the Liver.

Keywords

Cohort
Muscle
Muscle strength
Nonalcoholic fatty liver disease
Sarcopenia
Skeletal

ASJC Scopus subject areas

Hepatology

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10.1007/s12072-021-10258-8

Cite this

Roh, E., Hwang, S. Y., Yoo, H. J., Baik, S. H., Lee, J. H., Son, S. J., Kim, H. J., Park, Y. S., Lee, S. G., Cho, B. L., Jang, H. C., Kim, B. J., Kim, M., Won, C. W., & Choi, K. M. (2022). Impact of non-alcoholic fatty liver disease on the risk of sarcopenia: a nationwide multicenter prospective study. Hepatology International, 16(3), 545-554. https://doi.org/10.1007/s12072-021-10258-8

@article{d03202f720f34ac3b70273f4fab40265,

title = "Impact of non-alcoholic fatty liver disease on the risk of sarcopenia: a nationwide multicenter prospective study",

abstract = "Background and aims: Despite the association between sarcopenia and non-alcoholic fatty liver disease (NAFLD), no study has evaluated the predictive role of NAFLD in sarcopenia. We investigated impact of NAFLD on the risk of low muscle mass (LMM) and low muscle strength (LMS) in a nationwide multicenter study. Methods: A total of 1595 community-dwelling people aged 70–84 years were followed for 2 years in the Korean Frailty and Aging Cohort Study. Muscle mass was estimated by dividing appendicular skeletal muscle mass (ASM) by body mass index (BMI). Muscle strength was measured as handgrip strength (HGS) divided by BMI. The sex-specific lowest quintiles of ASM/BMI and HGS/BMI of the study population were used as cutoffs for LMM and LMS, respectively. The risk of LMM and LMS were assessed according to hepatic steatosis index (HSI) and fatty liver index (FLI) quartiles. Results: As HSI quartiles increased, the LMM risk increased gradually, after adjusting for age, sex, lifestyle factors, comorbidities, and several causative factors (insulin resistance, inflammation, and vitamin D) (Q4 vs. Q1 OR [95% CI] 3.46 [2.23–5.35]). The increased risk of LMS was even higher according to HSI quartiles (Q4 vs. Q1 5.81 [3.67–9.21]). Multivariate analyses based on FLI showed similar results. People with NAFLD (HSI > 36) were at higher risk of developing LMM and LMS compared to those without (1.65 [1.19–2.31] and 2.29 [1.61–3.26], respectively). Conclusions: The presence of NAFLD may predict future risk of LMM and LMS, with greater impact on LMS than on LMM. Graphic abstract: [Figure not available: see fulltext.]",

keywords = "Cohort, Muscle, Muscle strength, Nonalcoholic fatty liver disease, Sarcopenia, Skeletal",

author = "Eun Roh and Hwang, {Soon Young} and Yoo, {Hye Jin} and Baik, {Sei Hyun} and Lee, {Jin Hee} and Son, {Sang Joon} and Kim, {Hyeon Ju} and Park, {Yong Soon} and Lee, {Sam Gyu} and Cho, {Be Long} and Jang, {Hak Chul} and Kim, {Bong Jo} and Miji Kim and Won, {Chang Won} and Choi, {Kyung Mook}",

note = "Funding Information: This study was supported by grant from the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare of Korea (grant number: HI15C3153) and grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Education of Korea (grant number: 2020R1I1A1A01070499) This work was also supported by Korea University Guro Hospital (Korea Research-Driven Hospital) and grant funded by Korea University Medicine (K2115701). Publisher Copyright: {\textcopyright} 2021, Asian Pacific Association for the Study of the Liver.",

year = "2022",

month = jun,

doi = "10.1007/s12072-021-10258-8",

language = "English",

volume = "16",

pages = "545--554",

journal = "Hepatology International",

issn = "1936-0533",

publisher = "Springer New York",

number = "3",

}

TY - JOUR

T1 - Impact of non-alcoholic fatty liver disease on the risk of sarcopenia

T2 - a nationwide multicenter prospective study

AU - Roh, Eun

AU - Hwang, Soon Young

AU - Yoo, Hye Jin

AU - Baik, Sei Hyun

AU - Lee, Jin Hee

AU - Son, Sang Joon

AU - Kim, Hyeon Ju

AU - Park, Yong Soon

AU - Lee, Sam Gyu

AU - Cho, Be Long

AU - Jang, Hak Chul

AU - Kim, Bong Jo

AU - Kim, Miji

AU - Won, Chang Won

AU - Choi, Kyung Mook

N1 - Funding Information: This study was supported by grant from the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI) funded by the Ministry of Health and Welfare of Korea (grant number: HI15C3153) and grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Education of Korea (grant number: 2020R1I1A1A01070499) This work was also supported by Korea University Guro Hospital (Korea Research-Driven Hospital) and grant funded by Korea University Medicine (K2115701). Publisher Copyright: © 2021, Asian Pacific Association for the Study of the Liver.

PY - 2022/6

Y1 - 2022/6

N2 - Background and aims: Despite the association between sarcopenia and non-alcoholic fatty liver disease (NAFLD), no study has evaluated the predictive role of NAFLD in sarcopenia. We investigated impact of NAFLD on the risk of low muscle mass (LMM) and low muscle strength (LMS) in a nationwide multicenter study. Methods: A total of 1595 community-dwelling people aged 70–84 years were followed for 2 years in the Korean Frailty and Aging Cohort Study. Muscle mass was estimated by dividing appendicular skeletal muscle mass (ASM) by body mass index (BMI). Muscle strength was measured as handgrip strength (HGS) divided by BMI. The sex-specific lowest quintiles of ASM/BMI and HGS/BMI of the study population were used as cutoffs for LMM and LMS, respectively. The risk of LMM and LMS were assessed according to hepatic steatosis index (HSI) and fatty liver index (FLI) quartiles. Results: As HSI quartiles increased, the LMM risk increased gradually, after adjusting for age, sex, lifestyle factors, comorbidities, and several causative factors (insulin resistance, inflammation, and vitamin D) (Q4 vs. Q1 OR [95% CI] 3.46 [2.23–5.35]). The increased risk of LMS was even higher according to HSI quartiles (Q4 vs. Q1 5.81 [3.67–9.21]). Multivariate analyses based on FLI showed similar results. People with NAFLD (HSI > 36) were at higher risk of developing LMM and LMS compared to those without (1.65 [1.19–2.31] and 2.29 [1.61–3.26], respectively). Conclusions: The presence of NAFLD may predict future risk of LMM and LMS, with greater impact on LMS than on LMM. Graphic abstract: [Figure not available: see fulltext.]

AB - Background and aims: Despite the association between sarcopenia and non-alcoholic fatty liver disease (NAFLD), no study has evaluated the predictive role of NAFLD in sarcopenia. We investigated impact of NAFLD on the risk of low muscle mass (LMM) and low muscle strength (LMS) in a nationwide multicenter study. Methods: A total of 1595 community-dwelling people aged 70–84 years were followed for 2 years in the Korean Frailty and Aging Cohort Study. Muscle mass was estimated by dividing appendicular skeletal muscle mass (ASM) by body mass index (BMI). Muscle strength was measured as handgrip strength (HGS) divided by BMI. The sex-specific lowest quintiles of ASM/BMI and HGS/BMI of the study population were used as cutoffs for LMM and LMS, respectively. The risk of LMM and LMS were assessed according to hepatic steatosis index (HSI) and fatty liver index (FLI) quartiles. Results: As HSI quartiles increased, the LMM risk increased gradually, after adjusting for age, sex, lifestyle factors, comorbidities, and several causative factors (insulin resistance, inflammation, and vitamin D) (Q4 vs. Q1 OR [95% CI] 3.46 [2.23–5.35]). The increased risk of LMS was even higher according to HSI quartiles (Q4 vs. Q1 5.81 [3.67–9.21]). Multivariate analyses based on FLI showed similar results. People with NAFLD (HSI > 36) were at higher risk of developing LMM and LMS compared to those without (1.65 [1.19–2.31] and 2.29 [1.61–3.26], respectively). Conclusions: The presence of NAFLD may predict future risk of LMM and LMS, with greater impact on LMS than on LMM. Graphic abstract: [Figure not available: see fulltext.]

KW - Cohort

KW - Muscle

KW - Muscle strength

KW - Nonalcoholic fatty liver disease

KW - Sarcopenia

KW - Skeletal

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U2 - 10.1007/s12072-021-10258-8

DO - 10.1007/s12072-021-10258-8

M3 - Article

AN - SCOPUS:85118971091

SN - 1936-0533

VL - 16

SP - 545

EP - 554

JO - Hepatology International

JF - Hepatology International

IS - 3

ER -

Impact of non-alcoholic fatty liver disease on the risk of sarcopenia: a nationwide multicenter prospective study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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