Impact of stent designs of second-generation drug-eluting stents on long-term outcomes in coronary bifurcation lesions

Woo Jin Jang, Woo Jung Chun, Ik Hyun Park, Ki Hong Choi, Young Bin Song, Bon Kwon Koo, Joon Hyung Doh, Soon Jun Hong, Chang Wook Nam, Hyeon Cheol Gwon

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Objectives: We compared the long-term clinical outcomes of four different types of second-generation drug-eluting stents (DESs) in coronary bifurcation lesions. Background: Clinical outcomes of different designs of second-generation DESs are not well known in bifurcation lesions. Methods: Patients who underwent percutaneous coronary intervention with second-generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus-eluting stent (BP-BES group, n = 514), platinum chromium everolimus-eluting stent (PtCr-EES group, n = 473), cobalt nickel zotarolimus-eluting stent (CoNi-ZES group, n = 736), or cobalt chromium everolimus-eluting stent (CoCr-EES group, n = 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results: For 5 years of follow-up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP-BES group, 8.2% for PtCr-EES group, 6.5% for CoNi-ZES group, and 8.6% for CoCr-EES group, p =.434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively, p =.554). In subgroup analysis, the similarity of long-term outcomes among the four different types of second-generation DES was consistent across subgroups regardless of side branch treatment (p for interaction =.691). Conclusion: There seems to be no significant difference in long-term clinical outcomes among patients who received different types of second-generation DES for coronary bifurcation lesion.

Original languageEnglish
Pages (from-to)458-467
Number of pages10
JournalCatheterization and Cardiovascular Interventions
Issue number3
Publication statusPublished - 2021 Sept
Externally publishedYes


  • coronary bifurcation lesion
  • percutaneous coronary intervention
  • second-generation drug-eluting stent

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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