Impact of stent designs of second-generation drug-eluting stents on long-term outcomes in coronary bifurcation lesions

Woo Jin Jang; Woo Jung Chun; Ik Hyun Park; Ki Hong Choi; Young Bin Song; Bon Kwon Koo; Joon Hyung Doh; Soon Jun Hong; Chang Wook Nam; Hyeon Cheol Gwon

doi:10.1002/ccd.29137

Impact of stent designs of second-generation drug-eluting stents on long-term outcomes in coronary bifurcation lesions

Woo Jin Jang, Woo Jung Chun, Ik Hyun Park, Ki Hong Choi, Young Bin Song, Bon Kwon Koo, Joon Hyung Doh, Soon Jun Hong, Chang Wook Nam, Hyeon Cheol Gwon

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objectives: We compared the long-term clinical outcomes of four different types of second-generation drug-eluting stents (DESs) in coronary bifurcation lesions. Background: Clinical outcomes of different designs of second-generation DESs are not well known in bifurcation lesions. Methods: Patients who underwent percutaneous coronary intervention with second-generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus-eluting stent (BP-BES group, n = 514), platinum chromium everolimus-eluting stent (PtCr-EES group, n = 473), cobalt nickel zotarolimus-eluting stent (CoNi-ZES group, n = 736), or cobalt chromium everolimus-eluting stent (CoCr-EES group, n = 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results: For 5 years of follow-up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP-BES group, 8.2% for PtCr-EES group, 6.5% for CoNi-ZES group, and 8.6% for CoCr-EES group, p =.434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively, p =.554). In subgroup analysis, the similarity of long-term outcomes among the four different types of second-generation DES was consistent across subgroups regardless of side branch treatment (p for interaction =.691). Conclusion: There seems to be no significant difference in long-term clinical outcomes among patients who received different types of second-generation DES for coronary bifurcation lesion.

Original language	English
Pages (from-to)	458-467
Number of pages	10
Journal	Catheterization and Cardiovascular Interventions
Volume	98
Issue number	3
DOIs	https://doi.org/10.1002/ccd.29137
Publication status	Published - 2021 Sept
Externally published	Yes

Bibliographical note

Funding Information:
We thank Yong Hwan Park, MD, Ju Hyeon Oh, MD, Joo‐Yong Hahn, MD, Seung‐Hyuk Choi, MD, Hyo‐Soo Kim, MD, Seung‐Ho Hur, MD, Seung Hwan Han, MD, Seung‐Woon Rha, MD, In‐Ho Chae, MD, Jin‐Ok Jeong, MD, Jung Ho Heo, MD, Junghan Yoon, MD, Do‐Sun Lim, MD, Jong‐Seon Park, MD, Myeong‐Ki Hong, MD, Kwang Soo Cha, MD, Doo‐Il Kim, MD, Sang Yeub Lee, MD, Kiyuk Chang, MD, Byung‐Hee Hwang, MD, So‐Yeon Choi, MD, and Myung Ho Jeong, MD for collection, design, analysis, or interpretation of data. We also thank Jin‐Seob Kim, MD, MPH for his statistical support. This work was supported by Korean Bifurcation Club and Korean Society of Interventional Cardiology.

Publisher Copyright:
© 2020 Wiley Periodicals LLC.

Keywords

coronary bifurcation lesion
percutaneous coronary intervention
second-generation drug-eluting stent

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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@article{f958b4b5768c4bb08b0c4fd9f2a4a671,

title = "Impact of stent designs of second-generation drug-eluting stents on long-term outcomes in coronary bifurcation lesions",

abstract = "Objectives: We compared the long-term clinical outcomes of four different types of second-generation drug-eluting stents (DESs) in coronary bifurcation lesions. Background: Clinical outcomes of different designs of second-generation DESs are not well known in bifurcation lesions. Methods: Patients who underwent percutaneous coronary intervention with second-generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus-eluting stent (BP-BES group, n = 514), platinum chromium everolimus-eluting stent (PtCr-EES group, n = 473), cobalt nickel zotarolimus-eluting stent (CoNi-ZES group, n = 736), or cobalt chromium everolimus-eluting stent (CoCr-EES group, n = 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results: For 5 years of follow-up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP-BES group, 8.2% for PtCr-EES group, 6.5% for CoNi-ZES group, and 8.6% for CoCr-EES group, p =.434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively, p =.554). In subgroup analysis, the similarity of long-term outcomes among the four different types of second-generation DES was consistent across subgroups regardless of side branch treatment (p for interaction =.691). Conclusion: There seems to be no significant difference in long-term clinical outcomes among patients who received different types of second-generation DES for coronary bifurcation lesion.",

keywords = "coronary bifurcation lesion, percutaneous coronary intervention, second-generation drug-eluting stent",

author = "Jang, {Woo Jin} and Chun, {Woo Jung} and Park, {Ik Hyun} and Choi, {Ki Hong} and Song, {Young Bin} and Koo, {Bon Kwon} and Doh, {Joon Hyung} and Hong, {Soon Jun} and Nam, {Chang Wook} and Gwon, {Hyeon Cheol}",

note = "Funding Information: We thank Yong Hwan Park, MD, Ju Hyeon Oh, MD, Joo‐Yong Hahn, MD, Seung‐Hyuk Choi, MD, Hyo‐Soo Kim, MD, Seung‐Ho Hur, MD, Seung Hwan Han, MD, Seung‐Woon Rha, MD, In‐Ho Chae, MD, Jin‐Ok Jeong, MD, Jung Ho Heo, MD, Junghan Yoon, MD, Do‐Sun Lim, MD, Jong‐Seon Park, MD, Myeong‐Ki Hong, MD, Kwang Soo Cha, MD, Doo‐Il Kim, MD, Sang Yeub Lee, MD, Kiyuk Chang, MD, Byung‐Hee Hwang, MD, So‐Yeon Choi, MD, and Myung Ho Jeong, MD for collection, design, analysis, or interpretation of data. We also thank Jin‐Seob Kim, MD, MPH for his statistical support. This work was supported by Korean Bifurcation Club and Korean Society of Interventional Cardiology. Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC.",

year = "2021",

month = sep,

doi = "10.1002/ccd.29137",

language = "English",

volume = "98",

pages = "458--467",

journal = "Catheterization and Cardiovascular Interventions",

issn = "1522-1946",

publisher = "Wiley-Liss Inc.",

number = "3",

}

TY - JOUR

T1 - Impact of stent designs of second-generation drug-eluting stents on long-term outcomes in coronary bifurcation lesions

AU - Jang, Woo Jin

AU - Chun, Woo Jung

AU - Park, Ik Hyun

AU - Choi, Ki Hong

AU - Song, Young Bin

AU - Koo, Bon Kwon

AU - Doh, Joon Hyung

AU - Hong, Soon Jun

AU - Nam, Chang Wook

AU - Gwon, Hyeon Cheol

N1 - Funding Information: We thank Yong Hwan Park, MD, Ju Hyeon Oh, MD, Joo‐Yong Hahn, MD, Seung‐Hyuk Choi, MD, Hyo‐Soo Kim, MD, Seung‐Ho Hur, MD, Seung Hwan Han, MD, Seung‐Woon Rha, MD, In‐Ho Chae, MD, Jin‐Ok Jeong, MD, Jung Ho Heo, MD, Junghan Yoon, MD, Do‐Sun Lim, MD, Jong‐Seon Park, MD, Myeong‐Ki Hong, MD, Kwang Soo Cha, MD, Doo‐Il Kim, MD, Sang Yeub Lee, MD, Kiyuk Chang, MD, Byung‐Hee Hwang, MD, So‐Yeon Choi, MD, and Myung Ho Jeong, MD for collection, design, analysis, or interpretation of data. We also thank Jin‐Seob Kim, MD, MPH for his statistical support. This work was supported by Korean Bifurcation Club and Korean Society of Interventional Cardiology. Publisher Copyright: © 2020 Wiley Periodicals LLC.

PY - 2021/9

Y1 - 2021/9

N2 - Objectives: We compared the long-term clinical outcomes of four different types of second-generation drug-eluting stents (DESs) in coronary bifurcation lesions. Background: Clinical outcomes of different designs of second-generation DESs are not well known in bifurcation lesions. Methods: Patients who underwent percutaneous coronary intervention with second-generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus-eluting stent (BP-BES group, n = 514), platinum chromium everolimus-eluting stent (PtCr-EES group, n = 473), cobalt nickel zotarolimus-eluting stent (CoNi-ZES group, n = 736), or cobalt chromium everolimus-eluting stent (CoCr-EES group, n = 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results: For 5 years of follow-up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP-BES group, 8.2% for PtCr-EES group, 6.5% for CoNi-ZES group, and 8.6% for CoCr-EES group, p =.434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively, p =.554). In subgroup analysis, the similarity of long-term outcomes among the four different types of second-generation DES was consistent across subgroups regardless of side branch treatment (p for interaction =.691). Conclusion: There seems to be no significant difference in long-term clinical outcomes among patients who received different types of second-generation DES for coronary bifurcation lesion.

AB - Objectives: We compared the long-term clinical outcomes of four different types of second-generation drug-eluting stents (DESs) in coronary bifurcation lesions. Background: Clinical outcomes of different designs of second-generation DESs are not well known in bifurcation lesions. Methods: Patients who underwent percutaneous coronary intervention with second-generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus-eluting stent (BP-BES group, n = 514), platinum chromium everolimus-eluting stent (PtCr-EES group, n = 473), cobalt nickel zotarolimus-eluting stent (CoNi-ZES group, n = 736), or cobalt chromium everolimus-eluting stent (CoCr-EES group, n = 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results: For 5 years of follow-up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP-BES group, 8.2% for PtCr-EES group, 6.5% for CoNi-ZES group, and 8.6% for CoCr-EES group, p =.434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively, p =.554). In subgroup analysis, the similarity of long-term outcomes among the four different types of second-generation DES was consistent across subgroups regardless of side branch treatment (p for interaction =.691). Conclusion: There seems to be no significant difference in long-term clinical outcomes among patients who received different types of second-generation DES for coronary bifurcation lesion.

KW - coronary bifurcation lesion

KW - percutaneous coronary intervention

KW - second-generation drug-eluting stent

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U2 - 10.1002/ccd.29137

DO - 10.1002/ccd.29137

M3 - Article

AN - SCOPUS:85088805892

SN - 1522-1946

VL - 98

SP - 458

EP - 467

JO - Catheterization and Cardiovascular Interventions

JF - Catheterization and Cardiovascular Interventions

IS - 3

ER -

Impact of stent designs of second-generation drug-eluting stents on long-term outcomes in coronary bifurcation lesions

Abstract

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Keywords

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