Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder

B. T. Lee; H. Y. Lee; B. C. Lee; C. U. Pae; B. J. Yoon; S. G. Ryu; I. G. Choi; M. S. Lee; B. J. Ham

doi:10.1111/j.1601-183X.2009.00500.x

Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder

B. T. Lee, H. Y. Lee, B. C. Lee, C. U. Pae, B. J. Yoon, S. G. Ryu, I. G. Choi, M. S. Lee, B. J. Ham

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Using 1.5-Tesla functional magnetic resonance imaging, we investigated the possible relationship between TPH1 A218C polymorphism and amygdala response to negative facial stimuli in 26 right-handed female subjects with major depressive disorder (MDD). Genotyping was performed with the polymerase chain reaction. We found a significant association between A allele of the TPH1 A218C polymorphism and neural activations in response to negative facial stimuli. Subjects with the A allele of the TPH1 A218C polymorphism showed greater brain activity in the bilateral amygdala under the sad vs. the neutral condition compared with subjects homozygous for the C allele. Our results suggest that the A218C polymorphism of the TPH1 gene serves as a modulator of amygdala activity in patients with MDD.

Original language	English
Pages (from-to)	512-518
Number of pages	7
Journal	Genes, Brain and Behavior
Volume	8
Issue number	5
DOIs	https://doi.org/10.1111/j.1601-183X.2009.00500.x
Publication status	Published - 2009 Jul

Keywords

Anger
Functional magnetic resonance imaging
Major depressive disorder
Polymorphism
Sadness
Tryptophan hydroxylase

ASJC Scopus subject areas

Genetics
Neurology
Behavioral Neuroscience

Access to Document

10.1111/j.1601-183X.2009.00500.x

Cite this

Lee, B. T., Lee, H. Y., Lee, B. C., Pae, C. U., Yoon, B. J., Ryu, S. G., Choi, I. G., Lee, M. S., & Ham, B. J. (2009). Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder. Genes, Brain and Behavior, 8(5), 512-518. https://doi.org/10.1111/j.1601-183X.2009.00500.x

@article{ea1e3b264b44430685d54371370a9acd,

title = "Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder",

abstract = "Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Using 1.5-Tesla functional magnetic resonance imaging, we investigated the possible relationship between TPH1 A218C polymorphism and amygdala response to negative facial stimuli in 26 right-handed female subjects with major depressive disorder (MDD). Genotyping was performed with the polymerase chain reaction. We found a significant association between A allele of the TPH1 A218C polymorphism and neural activations in response to negative facial stimuli. Subjects with the A allele of the TPH1 A218C polymorphism showed greater brain activity in the bilateral amygdala under the sad vs. the neutral condition compared with subjects homozygous for the C allele. Our results suggest that the A218C polymorphism of the TPH1 gene serves as a modulator of amygdala activity in patients with MDD.",

keywords = "Anger, Functional magnetic resonance imaging, Major depressive disorder, Polymorphism, Sadness, Tryptophan hydroxylase",

author = "Lee, {B. T.} and Lee, {H. Y.} and Lee, {B. C.} and Pae, {C. U.} and Yoon, {B. J.} and Ryu, {S. G.} and Choi, {I. G.} and Lee, {M. S.} and Ham, {B. J.}",

year = "2009",

month = jul,

doi = "10.1111/j.1601-183X.2009.00500.x",

language = "English",

volume = "8",

pages = "512--518",

journal = "Genes, Brain and Behavior",

issn = "1601-1848",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder

AU - Lee, B. T.

AU - Lee, H. Y.

AU - Lee, B. C.

AU - Pae, C. U.

AU - Yoon, B. J.

AU - Ryu, S. G.

AU - Choi, I. G.

AU - Lee, M. S.

AU - Ham, B. J.

PY - 2009/7

Y1 - 2009/7

N2 - Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Using 1.5-Tesla functional magnetic resonance imaging, we investigated the possible relationship between TPH1 A218C polymorphism and amygdala response to negative facial stimuli in 26 right-handed female subjects with major depressive disorder (MDD). Genotyping was performed with the polymerase chain reaction. We found a significant association between A allele of the TPH1 A218C polymorphism and neural activations in response to negative facial stimuli. Subjects with the A allele of the TPH1 A218C polymorphism showed greater brain activity in the bilateral amygdala under the sad vs. the neutral condition compared with subjects homozygous for the C allele. Our results suggest that the A218C polymorphism of the TPH1 gene serves as a modulator of amygdala activity in patients with MDD.

AB - Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Using 1.5-Tesla functional magnetic resonance imaging, we investigated the possible relationship between TPH1 A218C polymorphism and amygdala response to negative facial stimuli in 26 right-handed female subjects with major depressive disorder (MDD). Genotyping was performed with the polymerase chain reaction. We found a significant association between A allele of the TPH1 A218C polymorphism and neural activations in response to negative facial stimuli. Subjects with the A allele of the TPH1 A218C polymorphism showed greater brain activity in the bilateral amygdala under the sad vs. the neutral condition compared with subjects homozygous for the C allele. Our results suggest that the A218C polymorphism of the TPH1 gene serves as a modulator of amygdala activity in patients with MDD.

KW - Anger

KW - Functional magnetic resonance imaging

KW - Major depressive disorder

KW - Polymorphism

KW - Sadness

KW - Tryptophan hydroxylase

UR - http://www.scopus.com/inward/record.url?scp=67650481364&partnerID=8YFLogxK

U2 - 10.1111/j.1601-183X.2009.00500.x

DO - 10.1111/j.1601-183X.2009.00500.x

M3 - Article

C2 - 19500158

AN - SCOPUS:67650481364

SN - 1601-1848

VL - 8

SP - 512

EP - 518

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

IS - 5

ER -

Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this