Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin

Yangsik Kim; Esther Yang; Hyun Kim

doi:10.1016/j.bbrc.2021.11.049

Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin

Yangsik Kim, Esther Yang, Hyun Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Prepulse inhibition (PPI) is a neurophysiological finding that is decreased in schizophrenia patients and has been used in pathophysiology studies of schizophrenia and the development of antipsychotic drugs. PPI is affected by several drugs including amphetamine, ketamine, and nicotinic agents, and it is reported that several brain regions and modulatory neurotransmitters are involved in PPI. Here we showed that mice with IRSp53 deletion in each dopaminergic, cholinergic, oxytocinergic, and serotoninergic modulatory neurons showed a decrease in PPI. Other than PPI, there were no other behavioral changes among IRSp53 deletion mice. Through this study, we could reconfirm that dysfunction of each modulatory neuron such as dopamine, acetylcholine, oxytocin, and serotonin can result in PPI impairment, and it should be considered that PPI could be broadly affected by changes in one of a certain kind of modulatory neurons.

Original language	English
Pages (from-to)	114-120
Number of pages	7
Journal	Biochemical and biophysical research communications
Volume	586
DOIs	https://doi.org/10.1016/j.bbrc.2021.11.049
Publication status	Published - 2022 Jan 1

Bibliographical note

Funding Information:
This work was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education ( NRF-2021R1C1C1003266 to Y.K.) and the intramural study from National Center for Mental Health in South Korea ( R2021-C to Y.K.).

Publisher Copyright:
© 2021 Elsevier Inc.

Keywords

Acetylcholine
Dopamine
IRSp53
Oxytocin
Prepulse inhibition
Schizophrenia
Serotonin

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2021.11.049

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title = "Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin",

abstract = "Prepulse inhibition (PPI) is a neurophysiological finding that is decreased in schizophrenia patients and has been used in pathophysiology studies of schizophrenia and the development of antipsychotic drugs. PPI is affected by several drugs including amphetamine, ketamine, and nicotinic agents, and it is reported that several brain regions and modulatory neurotransmitters are involved in PPI. Here we showed that mice with IRSp53 deletion in each dopaminergic, cholinergic, oxytocinergic, and serotoninergic modulatory neurons showed a decrease in PPI. Other than PPI, there were no other behavioral changes among IRSp53 deletion mice. Through this study, we could reconfirm that dysfunction of each modulatory neuron such as dopamine, acetylcholine, oxytocin, and serotonin can result in PPI impairment, and it should be considered that PPI could be broadly affected by changes in one of a certain kind of modulatory neurons.",

keywords = "Acetylcholine, Dopamine, IRSp53, Oxytocin, Prepulse inhibition, Schizophrenia, Serotonin",

author = "Yangsik Kim and Esther Yang and Hyun Kim",

note = "Funding Information: This work was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education ( NRF-2021R1C1C1003266 to Y.K.) and the intramural study from National Center for Mental Health in South Korea ( R2021-C to Y.K.). Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

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doi = "10.1016/j.bbrc.2021.11.049",

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AU - Kim, Yangsik

AU - Yang, Esther

AU - Kim, Hyun

N1 - Funding Information: This work was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education ( NRF-2021R1C1C1003266 to Y.K.) and the intramural study from National Center for Mental Health in South Korea ( R2021-C to Y.K.). Publisher Copyright: © 2021 Elsevier Inc.

PY - 2022/1/1

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N2 - Prepulse inhibition (PPI) is a neurophysiological finding that is decreased in schizophrenia patients and has been used in pathophysiology studies of schizophrenia and the development of antipsychotic drugs. PPI is affected by several drugs including amphetamine, ketamine, and nicotinic agents, and it is reported that several brain regions and modulatory neurotransmitters are involved in PPI. Here we showed that mice with IRSp53 deletion in each dopaminergic, cholinergic, oxytocinergic, and serotoninergic modulatory neurons showed a decrease in PPI. Other than PPI, there were no other behavioral changes among IRSp53 deletion mice. Through this study, we could reconfirm that dysfunction of each modulatory neuron such as dopamine, acetylcholine, oxytocin, and serotonin can result in PPI impairment, and it should be considered that PPI could be broadly affected by changes in one of a certain kind of modulatory neurons.

AB - Prepulse inhibition (PPI) is a neurophysiological finding that is decreased in schizophrenia patients and has been used in pathophysiology studies of schizophrenia and the development of antipsychotic drugs. PPI is affected by several drugs including amphetamine, ketamine, and nicotinic agents, and it is reported that several brain regions and modulatory neurotransmitters are involved in PPI. Here we showed that mice with IRSp53 deletion in each dopaminergic, cholinergic, oxytocinergic, and serotoninergic modulatory neurons showed a decrease in PPI. Other than PPI, there were no other behavioral changes among IRSp53 deletion mice. Through this study, we could reconfirm that dysfunction of each modulatory neuron such as dopamine, acetylcholine, oxytocin, and serotonin can result in PPI impairment, and it should be considered that PPI could be broadly affected by changes in one of a certain kind of modulatory neurons.

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KW - Dopamine

KW - IRSp53

KW - Oxytocin

KW - Prepulse inhibition

KW - Schizophrenia

KW - Serotonin

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ER -

Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin

Abstract

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Keywords

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