TY - JOUR
T1 - Implications of pericardial, visceral and subcutaneous adipose tissue on vascular inflammation measured using 18FDG-PET/CT
AU - Hong, Ho Cheol
AU - Hwang, Soon Young
AU - Park, Soyeon
AU - Ryu, Ja Young
AU - Choi, Hae Yoon
AU - Yoo, Hye Jin
AU - Seo, Ji A.
AU - Kim, Sin Gon
AU - Kim, Nan Hee
AU - Baik, Sei Hyun
AU - Choi, Dong Seop
AU - Kim, Sungeun
AU - Choi, Kyung Mook
N1 - Publisher Copyright:
© 2015 Hong et al.
PY - 2015/8/13
Y1 - 2015/8/13
N2 - Objective: Pericardial adipose tissue (PAT) is associated with adverse cardiometabolic risk factors and cardiovascular disease (CVD). However, the relative implications of PAT, abdominal visceral and subcutaneous adipose tissue on vascular inflammation have not been explored. Method and Results: We compared the association of PAT, abdominal visceral fat area (VFA), and subcutaneous fat area (SFA) with vascular inflammation, represented as the target-to-background ratio (TBR), the blood-normalized standardized uptake value measured using 18F-Fluorodeoxyglucose Positron Emission Tomography (18FDG-PET) in 93 men and women without diabetes or CVD. Age- and sex-adjusted correlation analysis showed that PAT, VFA, and SFA were positively associated with most cardiometabolic risk factors, including systolic blood pressure, LDL-cholesterol, triglycerides, glucose, insulin resistance and high sensitive Creactive proteins (hsCRP), whereas they were negatively associated with HDL-cholesterol. In particular, the maximum TBR (maxTBR) values were positively correlated with PAT and VFA (r = 0.48 and r = 0.45, respectively; both P <0.001), whereas SFA showed a relatively weak positive relationship with maxTBR level (r = 0.31, P = 0.003). Conclusion: This study demonstrated that both PAT and VFA are significantly and similarly associated with vascular inflammation and various cardiometabolic risk profiles.
AB - Objective: Pericardial adipose tissue (PAT) is associated with adverse cardiometabolic risk factors and cardiovascular disease (CVD). However, the relative implications of PAT, abdominal visceral and subcutaneous adipose tissue on vascular inflammation have not been explored. Method and Results: We compared the association of PAT, abdominal visceral fat area (VFA), and subcutaneous fat area (SFA) with vascular inflammation, represented as the target-to-background ratio (TBR), the blood-normalized standardized uptake value measured using 18F-Fluorodeoxyglucose Positron Emission Tomography (18FDG-PET) in 93 men and women without diabetes or CVD. Age- and sex-adjusted correlation analysis showed that PAT, VFA, and SFA were positively associated with most cardiometabolic risk factors, including systolic blood pressure, LDL-cholesterol, triglycerides, glucose, insulin resistance and high sensitive Creactive proteins (hsCRP), whereas they were negatively associated with HDL-cholesterol. In particular, the maximum TBR (maxTBR) values were positively correlated with PAT and VFA (r = 0.48 and r = 0.45, respectively; both P <0.001), whereas SFA showed a relatively weak positive relationship with maxTBR level (r = 0.31, P = 0.003). Conclusion: This study demonstrated that both PAT and VFA are significantly and similarly associated with vascular inflammation and various cardiometabolic risk profiles.
UR - http://www.scopus.com/inward/record.url?scp=84943189642&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0135294
DO - 10.1371/journal.pone.0135294
M3 - Article
C2 - 26270050
AN - SCOPUS:84943189642
SN - 1932-6203
VL - 10
JO - PLoS One
JF - PLoS One
IS - 8
M1 - e0135294
ER -