Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: A multicenter retrospective study in Korean patients

Moon Seong Baek, Sang Min Lee, Chi Ryang Chung, Woo Hyun Cho, Young Jae Cho, Sunghoon Park, So My Koo, Jae Seung Jung, Seung Yong Park, Youjin Chang, Byung Ju Kang, Jung Hyun Kim, Jin Young Oh, So Hee Park, Jung Wan Yoo, Yun Su Sim, Sang Bum Hong

    Research output: Contribution to journalArticlepeer-review

    20 Citations (Scopus)


    Background: Although the utilization of extracorporeal membrane oxygenation (ECMO) is increasing and its technology is evolving, only a few epidemiologic reports have described the uses and outcomes of ECMO. The aim of this study was to investigate the changes in utilization and survival rate in patients supported with ECMO for severe respiratory failure in Korea. Methods: This was a multicenter study on consecutive patients who underwent ECMO across 16 hospitals in Korea. The records of all patients who required ECMO for acute respiratory failure between 2012 and 2015 were retrospectively reviewed, and the utilization of ECMO was analyzed over time. Results: During the study period, 5552 patients received ECMO in Korea as a whole, and a total of 2472 patients received ECMO at the participating 16 hospitals. We analyzed 487 (19.7%) patients who received ECMO for respiratory failure. The number of ECMO procedures provided for respiratory failure increased from 104 to 153 during the study period. The in-hospital survival rate increased from 30.8% to 35.9%. The use of prone positioning increased from 6.8% to 49.0% (p < 0.001), and the use of neuromuscular blockers also increased from 28.2% to 58.2% (p < 0.001). Multiple regression analysis showed that old age (OR 1.038 (95% CI 1.022, 1.054)), use of corticosteroid (OR 2.251 (95% CI 1.153, 4.397)), continuous renal replacement therapy (OR 2.196 (95% CI 1.135, 4.247)), driving pressure (OR 1.072 (95% CI 1.031, 1.114)), and prolonged ECMO duration (OR 1.020 (95% CI 1.003, 1.038)) were associated with increased odds of mortality. Conclusions: Utilization of ECMO and survival rates of patients who received ECMO for respiratory failure increased over time in Korea. The use of pre-ECMO prone positioning and neuromuscular blockers also increased during the same period.

    Original languageEnglish
    Article number1
    JournalCritical Care
    Issue number1
    Publication statusPublished - 2019 Jan 3

    Bibliographical note

    Funding Information:
    This study was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute funded by the Ministry of Health & Welfare, Republic of Korea (HC15C1507).

    Publisher Copyright:
    © 2019 The Author(s).


    • Extracorporeal membrane oxygenation
    • Survival
    • Utilization

    ASJC Scopus subject areas

    • Critical Care and Intensive Care Medicine


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