Abstract
Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.
| Original language | English |
|---|---|
| Pages (from-to) | 1233-1239 |
| Number of pages | 7 |
| Journal | Food Science and Biotechnology |
| Volume | 29 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2020 Sept 1 |
Bibliographical note
Funding Information:This study was supported by a grant from Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through Agri-Bioindustry Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (No. 116159-02), the National Research Foundation of Korea (NRF) and the Center for Women In Science, Engineering and Technology (WISET) Grant funded by the Ministry of Science and ICT (MSIT) under the Program for Returner into R&D (WISET-2018-625), and Korea University, Seoul, Korea.
Publisher Copyright:
© 2020, The Korean Society of Food Science and Technology.
Keywords
- Carboxymethyl cellulose
- Disintegration time
- Low molecular hyaluronic acid
- Mechanical properties
- Orodispersible film
ASJC Scopus subject areas
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology