Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition

Seulki Kim; Dong Hwa Cho; Dong Keon Kweon; Eun Hee Jang; Joo Yeon Hong; Seung Taik Lim

doi:10.1007/s10068-020-00771-1

Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition

Seulki Kim, Dong Hwa Cho, Dong Keon Kweon, Eun Hee Jang, Joo Yeon Hong, Seung Taik Lim

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.

Original language	English
Pages (from-to)	1233-1239
Number of pages	7
Journal	Food Science and Biotechnology
Volume	29
Issue number	9
DOIs	https://doi.org/10.1007/s10068-020-00771-1
Publication status	Published - 2020 Sept 1

Keywords

Carboxymethyl cellulose
Disintegration time
Low molecular hyaluronic acid
Mechanical properties
Orodispersible film

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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10.1007/s10068-020-00771-1

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title = "Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition",

abstract = "Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.",

keywords = "Carboxymethyl cellulose, Disintegration time, Low molecular hyaluronic acid, Mechanical properties, Orodispersible film",

author = "Seulki Kim and Cho, {Dong Hwa} and Kweon, {Dong Keon} and Jang, {Eun Hee} and Hong, {Joo Yeon} and Lim, {Seung Taik}",

note = "Funding Information: This study was supported by a grant from Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through Agri-Bioindustry Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (No. 116159-02), the National Research Foundation of Korea (NRF) and the Center for Women In Science, Engineering and Technology (WISET) Grant funded by the Ministry of Science and ICT (MSIT) under the Program for Returner into R&D (WISET-2018-625), and Korea University, Seoul, Korea. Publisher Copyright: {\textcopyright} 2020, The Korean Society of Food Science and Technology.",

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doi = "10.1007/s10068-020-00771-1",

language = "English",

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TY - JOUR

T1 - Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition

AU - Kim, Seulki

AU - Cho, Dong Hwa

AU - Kweon, Dong Keon

AU - Jang, Eun Hee

AU - Hong, Joo Yeon

AU - Lim, Seung Taik

N1 - Funding Information: This study was supported by a grant from Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry (IPET) through Agri-Bioindustry Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (No. 116159-02), the National Research Foundation of Korea (NRF) and the Center for Women In Science, Engineering and Technology (WISET) Grant funded by the Ministry of Science and ICT (MSIT) under the Program for Returner into R&D (WISET-2018-625), and Korea University, Seoul, Korea. Publisher Copyright: © 2020, The Korean Society of Food Science and Technology.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.

AB - Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.

KW - Carboxymethyl cellulose

KW - Disintegration time

KW - Low molecular hyaluronic acid

KW - Mechanical properties

KW - Orodispersible film

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Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition

Abstract

Keywords

ASJC Scopus subject areas

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