Improvement of testosterone deficiency by fermented Momordica charantia extracts in aging male rats

Kyeong Soo Lee; Hyun Pyo Kim; Hyun Jin Park; Young Geol Yoon

doi:10.1007/s10068-020-00872-x

Improvement of testosterone deficiency by fermented Momordica charantia extracts in aging male rats

Kyeong Soo Lee, Hyun Pyo Kim, Hyun Jin Park, Young Geol Yoon

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

This study evaluated the efficacy of Momordica charantia (MC; bitter melon) extracts against andropause symptoms. We fermented MC with Lactobacillus plantarum and verified the ability of the fermented MC extracts (FMEs) to control testosterone deficiency by using aging male rats as an animal model of andropause. FME administration considerably increased total and free testosterone levels, muscle mass, forced swimming time, and total and motile sperm counts in aging male rats. In contrast, sex hormone-binding globulin, retroperitoneal fat, serum cholesterol, and triglyceride levels were significantly reduced in the treated groups compared to the non-treated control aging male rats. Furthermore, we observed that FME enhanced the expression of testosterone biosynthesis-related genes but reduced the expression of testosterone degradation-related genes in a mouse Leydig cell line. These results suggest that FME has effective pharmacological activities that increase and restore free testosterone levels and that FME may be employed as a promising natural product for alleviating testosterone deficiency syndrome.

Original language	English
Pages (from-to)	443-454
Number of pages	12
Journal	Food Science and Biotechnology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1007/s10068-020-00872-x
Publication status	Published - 2021 Mar

Bibliographical note

Funding Information:
We are grateful to the members of the Biomedical Research Institute at Jungwon University for their care and assistance in the animal experiment. This work was supported by a Jungwon University Research Grant (2019-009).

Funding Information:
We are grateful to the members of the Biomedical Research Institute at Jungwon University for their care and assistance in the animal experiment. This work was supported by a Jungwon University Research Grant (2019-009).

Publisher Copyright:
© 2021, The Korean Society of Food Science and Technology.

Keywords

Andropause
Fermentation
Lactic acid bacteria
Male climacteric syndrome
Momordica charantia
Testosterone deficiency

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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10.1007/s10068-020-00872-x

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title = "Improvement of testosterone deficiency by fermented Momordica charantia extracts in aging male rats",

abstract = "This study evaluated the efficacy of Momordica charantia (MC; bitter melon) extracts against andropause symptoms. We fermented MC with Lactobacillus plantarum and verified the ability of the fermented MC extracts (FMEs) to control testosterone deficiency by using aging male rats as an animal model of andropause. FME administration considerably increased total and free testosterone levels, muscle mass, forced swimming time, and total and motile sperm counts in aging male rats. In contrast, sex hormone-binding globulin, retroperitoneal fat, serum cholesterol, and triglyceride levels were significantly reduced in the treated groups compared to the non-treated control aging male rats. Furthermore, we observed that FME enhanced the expression of testosterone biosynthesis-related genes but reduced the expression of testosterone degradation-related genes in a mouse Leydig cell line. These results suggest that FME has effective pharmacological activities that increase and restore free testosterone levels and that FME may be employed as a promising natural product for alleviating testosterone deficiency syndrome.",

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author = "Lee, {Kyeong Soo} and Kim, {Hyun Pyo} and Park, {Hyun Jin} and Yoon, {Young Geol}",

note = "Funding Information: We are grateful to the members of the Biomedical Research Institute at Jungwon University for their care and assistance in the animal experiment. This work was supported by a Jungwon University Research Grant (2019-009). Funding Information: We are grateful to the members of the Biomedical Research Institute at Jungwon University for their care and assistance in the animal experiment. This work was supported by a Jungwon University Research Grant (2019-009). Publisher Copyright: {\textcopyright} 2021, The Korean Society of Food Science and Technology.",

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N1 - Funding Information: We are grateful to the members of the Biomedical Research Institute at Jungwon University for their care and assistance in the animal experiment. This work was supported by a Jungwon University Research Grant (2019-009). Funding Information: We are grateful to the members of the Biomedical Research Institute at Jungwon University for their care and assistance in the animal experiment. This work was supported by a Jungwon University Research Grant (2019-009). Publisher Copyright: © 2021, The Korean Society of Food Science and Technology.

PY - 2021/3

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N2 - This study evaluated the efficacy of Momordica charantia (MC; bitter melon) extracts against andropause symptoms. We fermented MC with Lactobacillus plantarum and verified the ability of the fermented MC extracts (FMEs) to control testosterone deficiency by using aging male rats as an animal model of andropause. FME administration considerably increased total and free testosterone levels, muscle mass, forced swimming time, and total and motile sperm counts in aging male rats. In contrast, sex hormone-binding globulin, retroperitoneal fat, serum cholesterol, and triglyceride levels were significantly reduced in the treated groups compared to the non-treated control aging male rats. Furthermore, we observed that FME enhanced the expression of testosterone biosynthesis-related genes but reduced the expression of testosterone degradation-related genes in a mouse Leydig cell line. These results suggest that FME has effective pharmacological activities that increase and restore free testosterone levels and that FME may be employed as a promising natural product for alleviating testosterone deficiency syndrome.

AB - This study evaluated the efficacy of Momordica charantia (MC; bitter melon) extracts against andropause symptoms. We fermented MC with Lactobacillus plantarum and verified the ability of the fermented MC extracts (FMEs) to control testosterone deficiency by using aging male rats as an animal model of andropause. FME administration considerably increased total and free testosterone levels, muscle mass, forced swimming time, and total and motile sperm counts in aging male rats. In contrast, sex hormone-binding globulin, retroperitoneal fat, serum cholesterol, and triglyceride levels were significantly reduced in the treated groups compared to the non-treated control aging male rats. Furthermore, we observed that FME enhanced the expression of testosterone biosynthesis-related genes but reduced the expression of testosterone degradation-related genes in a mouse Leydig cell line. These results suggest that FME has effective pharmacological activities that increase and restore free testosterone levels and that FME may be employed as a promising natural product for alleviating testosterone deficiency syndrome.

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Improvement of testosterone deficiency by fermented Momordica charantia extracts in aging male rats

Abstract

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Keywords

ASJC Scopus subject areas

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