TY - GEN
T1 - Improving parenchyma segmentation by simultaneous estimation of tissue property T 1 map and group-wise registration of inversion recovery MR breast images
AU - Xing, Ye
AU - Xue, Zhong
AU - Englander, Sarah
AU - Schnall, Mitchell
AU - Shen, Dinggang
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - The parenchyma tissue in the breast has a strong relation with predictive biomarkers of breast cancer. To better segment parenchyma, we perform segmentation on estimated tissue property T 1 map. To improve the estimation of tissue property (T 1) which is the basis for parenchyma segmentation, we present an integrated algorithm for simultaneous T 1 map estimation, T 1 map based parenchyma segmentation and group-wise registration on series of inversion recovery magnetic resonance (MR) breast images. The advantage of using this integrated algorithm is that the simultaneous T 1 map estimation (E-step) and group-wise registration (R-step) could benefit each other and jointly improve parenchyma segmentation. In particular, in E-step, T 1 map based segmentation could help perform an edge-preserving smoothing on the tentatively estimated noisy T 1 map, and could also help provide tissue probability maps to be robustly registered in R-step. Meanwhile, the improved estimation of T 1 map could help segment parenchyma in a more accurate way. In R-step, for robust registration, the group-wise registration is performed on the tissue probability maps produced in E-step, rather than the original inversion recovery MR images, since tissue probability maps are the intrinsic tissue property which is invariant to the use of different imaging parameters. The better alignment of images achieved in R-step can help improve T 1 map estimation and indirectly the T 1 map based parenchyma segmentation. By iteratively performing E-step and R-step, we can simultaneously obtain better results for T 1 map estimation,T 1 map based segmentation, group-wise registration, and finally parenchyma segmentation.
AB - The parenchyma tissue in the breast has a strong relation with predictive biomarkers of breast cancer. To better segment parenchyma, we perform segmentation on estimated tissue property T 1 map. To improve the estimation of tissue property (T 1) which is the basis for parenchyma segmentation, we present an integrated algorithm for simultaneous T 1 map estimation, T 1 map based parenchyma segmentation and group-wise registration on series of inversion recovery magnetic resonance (MR) breast images. The advantage of using this integrated algorithm is that the simultaneous T 1 map estimation (E-step) and group-wise registration (R-step) could benefit each other and jointly improve parenchyma segmentation. In particular, in E-step, T 1 map based segmentation could help perform an edge-preserving smoothing on the tentatively estimated noisy T 1 map, and could also help provide tissue probability maps to be robustly registered in R-step. Meanwhile, the improved estimation of T 1 map could help segment parenchyma in a more accurate way. In R-step, for robust registration, the group-wise registration is performed on the tissue probability maps produced in E-step, rather than the original inversion recovery MR images, since tissue probability maps are the intrinsic tissue property which is invariant to the use of different imaging parameters. The better alignment of images achieved in R-step can help improve T 1 map estimation and indirectly the T 1 map based parenchyma segmentation. By iteratively performing E-step and R-step, we can simultaneously obtain better results for T 1 map estimation,T 1 map based segmentation, group-wise registration, and finally parenchyma segmentation.
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U2 - 10.1007/978-3-540-85988-8_41
DO - 10.1007/978-3-540-85988-8_41
M3 - Conference contribution
C2 - 18979765
AN - SCOPUS:58849106825
SN - 354085987X
SN - 9783540859871
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 342
EP - 350
BT - Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings
T2 - 11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
Y2 - 6 September 2008 through 10 September 2008
ER -