Abstract
Terahertz time-domain spectroscopy (THz-TDS) was applied to investigate the feasibility of in-situ measuring vitamin C content in commercial tablet products without any pretreatments. Characteristic absorption peaks of vitamin C were analyzed with quantum mechanical calculation to reveal the molecular origin of them. The peak appearing at 1.08 THz was then selected and tested for its suitability as a fingerprint signal for analyzing the vitamin C content in dietary supplement tablets. There are a couple of factors influencing THz absorbance other than concentration. Among those, the effects of tablet thickness and types of excipients in the tablet products were found to be significant, and were corrected with the calibration curve to determine vitamin C concentration in tablet forms. Furthermore, commercial tablet products in the market were analyzed using THz-TDS and the measured vitamin C contents were in good agreement with those determined using a reference method (high-performance liquid chromatography). Thus, our results suggest that THz-TDS can be used for the in-situ analysis of vitamin C in commercial tablet products.
| Original language | English |
|---|---|
| Pages (from-to) | 367-377 |
| Number of pages | 11 |
| Journal | Journal of Infrared, Millimeter, and Terahertz Waves |
| Volume | 39 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2018 Apr 1 |
Bibliographical note
Funding Information:Funding Information This research was supported by the Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology (NRF-2010-0020819).
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords
- Commercial tablet products
- Fingerprint
- Solid-state density functional theory
- Terahertz time-domain spectroscopy
- Vitamin C
ASJC Scopus subject areas
- Radiation
- Instrumentation
- Condensed Matter Physics
- Electrical and Electronic Engineering