In Vino Veritas: A Tale of Two Sirt1s?

Seung Hoi Koo, Marc Montminy

Research output: Contribution to journalShort surveypeer-review

52 Citations (Scopus)


Resveratrol increases life span in lower organisms by activating the NAD+-dependent histone deacetylase Sirt1. Studies by Lagouge et al. (2006) and Baur et al. (2006) now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1α.

Original languageEnglish
Pages (from-to)1091-1093
Number of pages3
Issue number6
Publication statusPublished - 2006 Dec 15
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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