@inproceedings{fa9d5487a9f94919aad114baf3511356,
title = "In vitro 3D colective angiogenic response under orchestrated multiple chemical gradients",
abstract = "Angiogenesis is a process requiring a coordinated guidance from multiple factors. We examined the effects of angiogenic endothelial cell sprouting under the gradient of soluble factors, VEGF and ANG-1. This resulted in a different cellular morphology than the condition with single factors; the presence of VEGF gradient induced a greater number of tip cells, and addition of ANG-1 to the VEGF gradient stabilized collectively migrating cells. Interestingly, as shown by the average filopodial angle measured, tip cell was affected by VEGF only when ANG-1 gradient was not present, possibly because the tip cells attached to stalk cells have reduced freedom.",
keywords = "Angiogenesis, Cell migration, Cell-on-a-chip",
author = "Jeon, {Jessie S.} and Yoojin Shin and Jeonghun Nam and Seungha Lee and Jung, {Gi Seok} and Sehyun Shin and Lee, {Sang Hoon} and Kamm, {Roger D.} and Seok Chung",
note = "Copyright: Copyright 2013 Elsevier B.V., All rights reserved.; 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",
year = "2010",
language = "English",
isbn = "9781618390622",
series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
pages = "944--946",
booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
}