Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy.
Bibliographical noteFunding Information:
This study was supported by Korea University Grant K1422261 and by a grant from the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea ( HI13C1501 ).
© 2017 The Korean Society of Industrial and Engineering Chemistry
- Anti-inflammatory effect
- Collagenase-induced Achilles tendinopathy
- Porous microspheres
- Tendon healing
ASJC Scopus subject areas
- General Chemical Engineering