TY - JOUR
T1 - In vitro bactericidal and anticancer activity of new metabolite, ARK42, isolated from Aspergillus repens K42
AU - Park, Je Won
AU - Song, Beom Seok
AU - Ryu, Dojin
AU - Lee, Chan
AU - Kim, Young Bae
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002/12
Y1 - 2002/12
N2 - A novel antibacteria metabolite, ARK42, was isolated from a xerophilic fungal strain K42, and identified as Aspergillus repens based on its morphological characteristics. The metabolite exhibited antibacterial activities towards Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa, with MICs of 25, 12.5, and 3.125 μg/ml, respectively, and killed Pseudomonas aeruginosa with minimal bactericidal concentration (MBC) of 12.5 μg/ml. Furthermore, anticancer activities were demonstrated against human colon cancer DLD-1 and lung cancer LXFL529 cells with an IC50 of 10 and 1 μg/ml, respectively.
AB - A novel antibacteria metabolite, ARK42, was isolated from a xerophilic fungal strain K42, and identified as Aspergillus repens based on its morphological characteristics. The metabolite exhibited antibacterial activities towards Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa, with MICs of 25, 12.5, and 3.125 μg/ml, respectively, and killed Pseudomonas aeruginosa with minimal bactericidal concentration (MBC) of 12.5 μg/ml. Furthermore, anticancer activities were demonstrated against human colon cancer DLD-1 and lung cancer LXFL529 cells with an IC50 of 10 and 1 μg/ml, respectively.
KW - Anticancer activity
KW - Aspergillus repens
KW - Bactericidal activity
UR - http://www.scopus.com/inward/record.url?scp=0037001090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037001090&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0037001090
SN - 1017-7825
VL - 12
SP - 1017
EP - 1021
JO - Journal of Microbiology and Biotechnology
JF - Journal of Microbiology and Biotechnology
IS - 6
ER -
