In vitro dynamic degradation behavior of new magnesium alloy for orthopedic applications

Gui Fu Yang; Yu Chan Kim; Hyung Seop Han; Gwang Chul Lee; Hyun Kwang Seok; Jae-chul Lee

doi:10.1002/jbm.b.33259

In vitro dynamic degradation behavior of new magnesium alloy for orthopedic applications

Gui Fu Yang
, Yu Chan Kim
, Hyung Seop Han
, Gwang Chul Lee
, Hyun Kwang Seok^*
, Jae-chul Lee

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

We report on methodologies for use in the design of a biodegradable Mg alloy appropriate for load-bearing but temporary orthopedic implant applications. Comparative studies of Mg-5Ca and Mg-5Ca-1Zn were conducted to explore the effects of a combination of minor alloying and hot extrusion, on the alloy's mechanical properties and corrosion resistance. The extruded Mg-5Ca-1Zn exhibited high ultimate compressive strength of 385 MPa and suffered no significant structural degradation even after immersion in simulated body fluid for 30 days. Mg-5Ca-1Zn alloy showed the mechanical strength and controlled corrosion rate to be considered as an ideal candidate for biodegradable orthopedic implant material.

Original language	English
Pages (from-to)	807-815
Number of pages	9
Journal	Journal of Biomedical Materials Research - Part B Applied Biomaterials
Volume	103
Issue number	4
DOIs	https://doi.org/10.1002/jbm.b.33259
Publication status	Published - 2015 May 1

Keywords

biodegradation
magnesium
mechanical properties
SEM
zinc

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials

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10.1002/jbm.b.33259

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title = "In vitro dynamic degradation behavior of new magnesium alloy for orthopedic applications",

abstract = "We report on methodologies for use in the design of a biodegradable Mg alloy appropriate for load-bearing but temporary orthopedic implant applications. Comparative studies of Mg-5Ca and Mg-5Ca-1Zn were conducted to explore the effects of a combination of minor alloying and hot extrusion, on the alloy's mechanical properties and corrosion resistance. The extruded Mg-5Ca-1Zn exhibited high ultimate compressive strength of 385 MPa and suffered no significant structural degradation even after immersion in simulated body fluid for 30 days. Mg-5Ca-1Zn alloy showed the mechanical strength and controlled corrosion rate to be considered as an ideal candidate for biodegradable orthopedic implant material.",

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AU - Yang, Gui Fu

AU - Kim, Yu Chan

AU - Han, Hyung Seop

AU - Lee, Gwang Chul

AU - Seok, Hyun Kwang

AU - Lee, Jae-chul

PY - 2015/5/1

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N2 - We report on methodologies for use in the design of a biodegradable Mg alloy appropriate for load-bearing but temporary orthopedic implant applications. Comparative studies of Mg-5Ca and Mg-5Ca-1Zn were conducted to explore the effects of a combination of minor alloying and hot extrusion, on the alloy's mechanical properties and corrosion resistance. The extruded Mg-5Ca-1Zn exhibited high ultimate compressive strength of 385 MPa and suffered no significant structural degradation even after immersion in simulated body fluid for 30 days. Mg-5Ca-1Zn alloy showed the mechanical strength and controlled corrosion rate to be considered as an ideal candidate for biodegradable orthopedic implant material.

AB - We report on methodologies for use in the design of a biodegradable Mg alloy appropriate for load-bearing but temporary orthopedic implant applications. Comparative studies of Mg-5Ca and Mg-5Ca-1Zn were conducted to explore the effects of a combination of minor alloying and hot extrusion, on the alloy's mechanical properties and corrosion resistance. The extruded Mg-5Ca-1Zn exhibited high ultimate compressive strength of 385 MPa and suffered no significant structural degradation even after immersion in simulated body fluid for 30 days. Mg-5Ca-1Zn alloy showed the mechanical strength and controlled corrosion rate to be considered as an ideal candidate for biodegradable orthopedic implant material.

KW - biodegradation

KW - magnesium

KW - mechanical properties

KW - SEM

KW - zinc

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In vitro dynamic degradation behavior of new magnesium alloy for orthopedic applications

Abstract

Keywords

ASJC Scopus subject areas

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