Abstract
Reconstruction of mammary duct in vitro is highly required to study breast cancer pathology in progressing invasive ductal carcinoma in situ (DCIS) [1]. 30% of DCIS cases were known to have invasive character, which is strongly associated with cancer malignancy. Understanding the invasive transition needs an in vitro model with modulating capability on microenvironment, consisting of mammary duct, stromal cells and extracellular matrix (ECM). Here, we mimicked the mammary duct in microfluidic platform in 3D on type I collagen ECM. Morphologies and functions of the mammary duct were confirmed by 3D lumen structure, junction proteins and permeability.
| Original language | English |
|---|---|
| Title of host publication | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 525-526 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780979806490 |
| Publication status | Published - 2016 |
| Event | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland Duration: 2016 Oct 9 → 2016 Oct 13 |
Publication series
| Name | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|
Other
| Other | 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 |
|---|---|
| Country/Territory | Ireland |
| City | Dublin |
| Period | 16/10/9 → 16/10/13 |
Bibliographical note
Funding Information:This research was supported by National Research Foundation of Korea (2014M3A7B4052193) funded by the Ministry of Science, ICT & Future Planning and the Technological Innovation R&D Program (C0398093) funded by the Small and Medium Business Administration(SMBA, Korea).
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
Keywords
- Mammary duct
- Microfluidics
ASJC Scopus subject areas
- Control and Systems Engineering
