In vitro metabolism of an estrogen-related receptor γ modulator, GSK5182, by human liver microsomes and recombinant cytochrome P450s

Biochemistry, Genetics and Molecular Biology

• Metabolic Pathway 100%
• Cytochrome 100%
• Metabolite 100%
• Estrogen-Related Receptor 100%
• Cytochrome P450 100%
• Isoform 66%
• Tandem Mass Spectrometry 66%
• Flavin-Containing Monooxygenase 66%
• Enzyme 33%
• Homeostasis 33%
• Demethylation 33%
• Pharmacokinetics 33%
• Hydroxylation 33%
• Liquid Chromatography-Mass Spectrometry 33%
• Orphan Nuclear Receptor 33%
• Inverse Agonist 33%
• Liquid Chromatography 33%
• CYP3A4 33%
• Drug Interaction 33%

Keyphrases

• Recombinant 100%
• Cytochrome P450 (CYP450) 100%
• Estrogen Receptor 100%
• GSK5182 100%
• Receptor Modulators 100%
• In Vitro Metabolism 100%
• Human Liver Microsomes 100%
• N-oxides 16%
• P450 16%
• Flavin-dependent Monooxygenase 16%
• Phenyl 8%
• Mass Spectrometry 8%
• Homeostasis 8%
• MS-MS 8%
• Chemical Inhibitors 8%
• Incubation 8%
• Metabolism 8%
• Correlation Analysis 8%
• Inverse Agonist 8%
• Nuclear Receptor 8%
• N-methylation 8%
• LC-MS Analysis 8%
• Orphan nuclear Receptor 8%
• Drug Interactions 8%
• Nicotinamide Adenine Dinucleotide Phosphate (NADPH) 8%
• Cytochrome P450 3A4 (CYP3A4) 8%
• FMO3 8%
• Desmethyl 8%
• Liquid Chromatography-tandem Mass 8%
• Liver Metabolism 8%
• Metabolite M1 8%
• FMO1 8%
• MS Fragmentation Pattern 8%
• N-hydroxylation 8%
• Pharmacokinetic Interaction 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Receptor 100%
• Cytochrome P450 100%
• Cytochrome 100%
• Dimethylaniline Monooxygenase 66%
• Inverse Agonist 33%
• Drug Interaction 33%
• Orphan Nuclear Receptor 33%
• CYP3A4 33%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate 33%
• Pharmacokinetics 33%
• Phenol 33%