In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

Youn Chul Kim; Hyuncheol Oh; Beom Seok Kim; Tai Hyun Kang; Eun Kyoung Ko; Yu Mi Han; Bo Yeon Kim; Jong Seog Ahn

doi:10.1055/s-2005-837759

In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

Youn Chul Kim, Hyuncheol Oh, Beom Seok Kim, Tai Hyun Kang, Eun Kyoung Ko, Yu Mi Han, Bo Yeon Kim, Jong Seog Ahn

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for B diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC₅₀ values of 9.4 ± 0.5 μM and 20.8 ± 1.9 μM, respectively.

Original language	English
Pages (from-to)	87-89
Number of pages	3
Journal	Planta Medica
Volume	71
Issue number	1
DOIs	https://doi.org/10.1055/s-2005-837759
Publication status	Published - 2005 Jan
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1055/s-2005-837759

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abstract = "Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for B diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC50 values of 9.4 ± 0.5 μM and 20.8 ± 1.9 μM, respectively.",

author = "Kim, {Youn Chul} and Hyuncheol Oh and Kim, {Beom Seok} and Kang, {Tai Hyun} and Ko, {Eun Kyoung} and Han, {Yu Mi} and Kim, {Bo Yeon} and Ahn, {Jong Seog}",

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AU - Kim, Youn Chul

AU - Oh, Hyuncheol

AU - Kim, Beom Seok

AU - Kang, Tai Hyun

AU - Ko, Eun Kyoung

AU - Han, Yu Mi

AU - Kim, Bo Yeon

AU - Ahn, Jong Seog

PY - 2005/1

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AB - Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for B diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC50 values of 9.4 ± 0.5 μM and 20.8 ± 1.9 μM, respectively.

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In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

Abstract

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