In vivo comparison of wound healing and scar treatment effect between curcumin–oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded-liposome

Minh Hiep Nguyen; Ngoc Bich Dao Vu; Thi Huynh Nga Nguyen; Hoang Sinh Le; Huu Tu Le; Thi Tam Tran; Xuan Cuong Le; Van Toan Le; Thi Thu Nguyen; Chi Bao Bui; Huyn Jin Park

doi:10.1080/02652048.2019.1612476

In vivo comparison of wound healing and scar treatment effect between curcumin–oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded-liposome

Minh Hiep Nguyen, Ngoc Bich Dao Vu, Thi Huynh Nga Nguyen, Hoang Sinh Le, Huu Tu Le, Thi Tam Tran, Xuan Cuong Le, Van Toan Le, Thi Thu Nguyen, Chi Bao Bui, Huyn Jin Park

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

This study aimed to compare the in vivo effectiveness between curcumin–oligochitosan nanoplexes (CUR–OCH nanoplexes) and oligochitosan-coated curcumin-encapsulated liposomes (OCH-Lip-CUR) with respect to wound healing and scar treatment. Firstly, CUR-OCH nanoplexes was prepared by drug-polysaccharide complexation method and OCH-Lip-CUR was prepared by a combining method of lipid-film hydration and sonication. Their in vitro cytotoxicity and in vivo wound healing and scar treatment effectiveness were evaluated using 3T3 cells and mice Mus musculus var. Albino, respectively. The resutls indicated that both of them were in nanosize with a moderate PDI (less than 0.3), and exhibited negligible cytotoxicity at low CUR concentration (0.01 mg/mL). Moreover, their application onto wounds resulted in faster healing and higher scar treatment effectiveness than control samples. Interestingly, OCH-Lip-CUR exhibited higher in vivo effectiveness than CUR-OCH nanoplexes. However, based on their own advantages, both of them were good candidates for a commercial formulation for wound healing and scar treatment.

Original language	English
Pages (from-to)	156-168
Number of pages	13
Journal	Journal of Microencapsulation
Volume	36
Issue number	2
DOIs	https://doi.org/10.1080/02652048.2019.1612476
Publication status	Published - 2019 Feb 17

Bibliographical note

Funding Information:
This study received research funding from Vietnam Atomic Energy Institute and Nuclear Research Institute (Grant number: 07/17/VNCHN). The authors would like to acknowledge the School of Life Sciences and Biotechnology, Korea University, South of Korea for the contribution to this work.

Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Curcumin
liposome
nanoplex
oligochitosan
scar treatment
wound healing

ASJC Scopus subject areas

Bioengineering
Pharmaceutical Science
Physical and Theoretical Chemistry
Organic Chemistry
Colloid and Surface Chemistry

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10.1080/02652048.2019.1612476

Cite this

Nguyen, M. H., Vu, N. B. D., Nguyen, T. H. N., Le, H. S., Le, H. T., Tran, T. T., Le, X. C., Le, V. T., Nguyen, T. T., Bui, C. B., & Park, H. J. (2019). In vivo comparison of wound healing and scar treatment effect between curcumin–oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded-liposome. Journal of Microencapsulation, 36(2), 156-168. https://doi.org/10.1080/02652048.2019.1612476

In vivo comparison of wound healing and scar treatment effect between curcumin–oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded-liposome. / Nguyen, Minh Hiep; Vu, Ngoc Bich Dao; Nguyen, Thi Huynh Nga et al.
In: Journal of Microencapsulation, Vol. 36, No. 2, 17.02.2019, p. 156-168.

Research output: Contribution to journal › Article › peer-review

Nguyen, MH, Vu, NBD, Nguyen, THN, Le, HS, Le, HT, Tran, TT, Le, XC, Le, VT, Nguyen, TT, Bui, CB & Park, HJ 2019, 'In vivo comparison of wound healing and scar treatment effect between curcumin–oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded-liposome', Journal of Microencapsulation, vol. 36, no. 2, pp. 156-168. https://doi.org/10.1080/02652048.2019.1612476

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abstract = "This study aimed to compare the in vivo effectiveness between curcumin–oligochitosan nanoplexes (CUR–OCH nanoplexes) and oligochitosan-coated curcumin-encapsulated liposomes (OCH-Lip-CUR) with respect to wound healing and scar treatment. Firstly, CUR-OCH nanoplexes was prepared by drug-polysaccharide complexation method and OCH-Lip-CUR was prepared by a combining method of lipid-film hydration and sonication. Their in vitro cytotoxicity and in vivo wound healing and scar treatment effectiveness were evaluated using 3T3 cells and mice Mus musculus var. Albino, respectively. The resutls indicated that both of them were in nanosize with a moderate PDI (less than 0.3), and exhibited negligible cytotoxicity at low CUR concentration (0.01 mg/mL). Moreover, their application onto wounds resulted in faster healing and higher scar treatment effectiveness than control samples. Interestingly, OCH-Lip-CUR exhibited higher in vivo effectiveness than CUR-OCH nanoplexes. However, based on their own advantages, both of them were good candidates for a commercial formulation for wound healing and scar treatment.",

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note = "Funding Information: This study received research funding from Vietnam Atomic Energy Institute and Nuclear Research Institute (Grant number: 07/17/VNCHN). The authors would like to acknowledge the School of Life Sciences and Biotechnology, Korea University, South of Korea for the contribution to this work. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

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AU - Vu, Ngoc Bich Dao

AU - Nguyen, Thi Huynh Nga

AU - Le, Hoang Sinh

AU - Le, Huu Tu

AU - Tran, Thi Tam

AU - Le, Xuan Cuong

AU - Le, Van Toan

AU - Nguyen, Thi Thu

AU - Bui, Chi Bao

AU - Park, Huyn Jin

N1 - Funding Information: This study received research funding from Vietnam Atomic Energy Institute and Nuclear Research Institute (Grant number: 07/17/VNCHN). The authors would like to acknowledge the School of Life Sciences and Biotechnology, Korea University, South of Korea for the contribution to this work. Publisher Copyright: © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2019/2/17

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N2 - This study aimed to compare the in vivo effectiveness between curcumin–oligochitosan nanoplexes (CUR–OCH nanoplexes) and oligochitosan-coated curcumin-encapsulated liposomes (OCH-Lip-CUR) with respect to wound healing and scar treatment. Firstly, CUR-OCH nanoplexes was prepared by drug-polysaccharide complexation method and OCH-Lip-CUR was prepared by a combining method of lipid-film hydration and sonication. Their in vitro cytotoxicity and in vivo wound healing and scar treatment effectiveness were evaluated using 3T3 cells and mice Mus musculus var. Albino, respectively. The resutls indicated that both of them were in nanosize with a moderate PDI (less than 0.3), and exhibited negligible cytotoxicity at low CUR concentration (0.01 mg/mL). Moreover, their application onto wounds resulted in faster healing and higher scar treatment effectiveness than control samples. Interestingly, OCH-Lip-CUR exhibited higher in vivo effectiveness than CUR-OCH nanoplexes. However, based on their own advantages, both of them were good candidates for a commercial formulation for wound healing and scar treatment.

AB - This study aimed to compare the in vivo effectiveness between curcumin–oligochitosan nanoplexes (CUR–OCH nanoplexes) and oligochitosan-coated curcumin-encapsulated liposomes (OCH-Lip-CUR) with respect to wound healing and scar treatment. Firstly, CUR-OCH nanoplexes was prepared by drug-polysaccharide complexation method and OCH-Lip-CUR was prepared by a combining method of lipid-film hydration and sonication. Their in vitro cytotoxicity and in vivo wound healing and scar treatment effectiveness were evaluated using 3T3 cells and mice Mus musculus var. Albino, respectively. The resutls indicated that both of them were in nanosize with a moderate PDI (less than 0.3), and exhibited negligible cytotoxicity at low CUR concentration (0.01 mg/mL). Moreover, their application onto wounds resulted in faster healing and higher scar treatment effectiveness than control samples. Interestingly, OCH-Lip-CUR exhibited higher in vivo effectiveness than CUR-OCH nanoplexes. However, based on their own advantages, both of them were good candidates for a commercial formulation for wound healing and scar treatment.

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In vivo comparison of wound healing and scar treatment effect between curcumin–oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded-liposome

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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