In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells

Taeseok Daniel Yang; Wonshik Choi; Tai Hyun Yoon; Kyoung Jin Lee; Jae Seung Lee; Jang Ho Joo; Min Goo Lee; Hong Soon Yim; Kyung Min Choi; Byoungjae Kim; Jung Joo Lee; Heejin Kim; Doh Young Lee; Kwang Yoon Jung; Seung Kuk Baek

doi:10.1364/BOE.7.000185

In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells

Taeseok Daniel Yang, Wonshik Choi, Tai Hyun Yoon, Kyoung Jin Lee, Jae Seung Lee, Jang Ho Joo, Min Goo Lee, Hong Soon Yim, Kyung Min Choi, Byoungjae Kim, Jung Joo Lee, Heejin Kim, Doh Young Lee, Kwang Yoon Jung, Seung Kuk Baek

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Photothermal treatment methods have been widely studied for their target specificity and potential for supplementing the limitations of conventional surgical treatments. In this study, we conducted in vivo photothermal treatments using macrophages containing nanoshells as live vectors. We injected macrophages at the peritumoral sites and observed that they had penetrated into the tumor approximately 48 hours after injection. Afterwards, we irradiated with a near-infrared laser for 2 minutes at 1 W/cm², causing cancer cell death. Our study identified the optimal conditions of the photothermal treatment and confirmed the feasibility of its use in in vivo treatments.

Original language	English
Pages (from-to)	185-193
Number of pages	9
Journal	Biomedical Optics Express
Volume	7
Issue number	1
DOIs	https://doi.org/10.1364/BOE.7.000185
Publication status	Published - 2015 Dec 18

Keywords

Medical optics and biotechnology
Photodynamic therapy
Photothermal effects

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1364/BOE.7.000185

Cite this

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title = "In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells",

abstract = "Photothermal treatment methods have been widely studied for their target specificity and potential for supplementing the limitations of conventional surgical treatments. In this study, we conducted in vivo photothermal treatments using macrophages containing nanoshells as live vectors. We injected macrophages at the peritumoral sites and observed that they had penetrated into the tumor approximately 48 hours after injection. Afterwards, we irradiated with a near-infrared laser for 2 minutes at 1 W/cm2, causing cancer cell death. Our study identified the optimal conditions of the photothermal treatment and confirmed the feasibility of its use in in vivo treatments.",

keywords = "Medical optics and biotechnology, Photodynamic therapy, Photothermal effects",

author = "Yang, {Taeseok Daniel} and Wonshik Choi and Yoon, {Tai Hyun} and Lee, {Kyoung Jin} and Lee, {Jae Seung} and Joo, {Jang Ho} and Lee, {Min Goo} and Yim, {Hong Soon} and Choi, {Kyung Min} and Byoungjae Kim and Lee, {Jung Joo} and Heejin Kim and Lee, {Doh Young} and Jung, {Kwang Yoon} and Baek, {Seung Kuk}",

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doi = "10.1364/BOE.7.000185",

language = "English",

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T1 - In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells

AU - Yang, Taeseok Daniel

AU - Choi, Wonshik

AU - Yoon, Tai Hyun

AU - Lee, Kyoung Jin

AU - Lee, Jae Seung

AU - Joo, Jang Ho

AU - Lee, Min Goo

AU - Yim, Hong Soon

AU - Choi, Kyung Min

AU - Kim, Byoungjae

AU - Lee, Jung Joo

AU - Kim, Heejin

AU - Lee, Doh Young

AU - Jung, Kwang Yoon

AU - Baek, Seung Kuk

PY - 2015/12/18

Y1 - 2015/12/18

N2 - Photothermal treatment methods have been widely studied for their target specificity and potential for supplementing the limitations of conventional surgical treatments. In this study, we conducted in vivo photothermal treatments using macrophages containing nanoshells as live vectors. We injected macrophages at the peritumoral sites and observed that they had penetrated into the tumor approximately 48 hours after injection. Afterwards, we irradiated with a near-infrared laser for 2 minutes at 1 W/cm2, causing cancer cell death. Our study identified the optimal conditions of the photothermal treatment and confirmed the feasibility of its use in in vivo treatments.

AB - Photothermal treatment methods have been widely studied for their target specificity and potential for supplementing the limitations of conventional surgical treatments. In this study, we conducted in vivo photothermal treatments using macrophages containing nanoshells as live vectors. We injected macrophages at the peritumoral sites and observed that they had penetrated into the tumor approximately 48 hours after injection. Afterwards, we irradiated with a near-infrared laser for 2 minutes at 1 W/cm2, causing cancer cell death. Our study identified the optimal conditions of the photothermal treatment and confirmed the feasibility of its use in in vivo treatments.

KW - Medical optics and biotechnology

KW - Photodynamic therapy

KW - Photothermal effects

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In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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