In vivo study of the renal protective effects of Capsosiphon fulvescens against streptozotocin-induced oxidative stress

Mi Hyun Nam; Yun Chang Koo; Chung Oui Hong; Sung Yong Yang; Se Wook Kim; Hye Lim Jung; Hwa Lee; Ji Yeon Kim; Ah Ram Han; Won Rak Son; Min Cheol Pyo; Kwang Won Lee

doi:10.9721/KJFST.2014.46.5.641

In vivo study of the renal protective effects of Capsosiphon fulvescens against streptozotocin-induced oxidative stress

Mi Hyun Nam, Yun Chang Koo, Chung Oui Hong, Sung Yong Yang, Se Wook Kim, Hye Lim Jung, Hwa Lee, Ji Yeon Kim, Ah Ram Han, Won Rak Son, Min Cheol Pyo, Kwang Won Lee

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In this study, we evaluated the effect of Capsosiphon fulvescens extract (CFE) and its active compound, pheophorbide A (PhA), on diabetic kidney failure. Diabetes mellitus (DM) was induced by a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight (BW)). After a week, the rats were orally administered CFE (4 and 20 mg/ kg BW) or PhA (0.2 mg/kg BW) once a day for 9 weeks. After scarification, renal tissue samples were collected for biochemical and histochemical analyses. Our study showed that the treatment with CFE and PhA significantly decreased lipid peroxidation level and the activities of glutathione peroxidase and glutathione-S-transferase (p<0.05), but it increased glutathione level and the activities of glutathione reductase, superoxide dismutase, and catalase in the renal tissues (p<0.05). The CFE- and PhA-treated rats with DM showed improved histochemical appearance and decreased abnormal glycogen accumulation. Therefore, we suggest that PhA-containing CFE could exert renal protective effects against STZ-induced oxidative stress.

Original language	English
Pages (from-to)	641-647
Number of pages	7
Journal	Korean Journal of Food Science and Technology
Volume	46
Issue number	5
DOIs	https://doi.org/10.9721/KJFST.2014.46.5.641
Publication status	Published - 2014 Oct 1

Keywords

Antioxidant enzyme
Capsosiphon fulvescens
Diabetic rats
Oxidative stress
Renal protective effects
Streptozotocin

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.9721/KJFST.2014.46.5.641

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Nam, M. H., Koo, Y. C., Hong, C. O., Yang, S. Y., Kim, S. W., Jung, H. L., Lee, H., Kim, J. Y., Han, A. R., Son, W. R., Pyo, M. C., & Lee, K. W. (2014). In vivo study of the renal protective effects of Capsosiphon fulvescens against streptozotocin-induced oxidative stress. Korean Journal of Food Science and Technology, 46(5), 641-647. https://doi.org/10.9721/KJFST.2014.46.5.641

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abstract = "In this study, we evaluated the effect of Capsosiphon fulvescens extract (CFE) and its active compound, pheophorbide A (PhA), on diabetic kidney failure. Diabetes mellitus (DM) was induced by a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight (BW)). After a week, the rats were orally administered CFE (4 and 20 mg/ kg BW) or PhA (0.2 mg/kg BW) once a day for 9 weeks. After scarification, renal tissue samples were collected for biochemical and histochemical analyses. Our study showed that the treatment with CFE and PhA significantly decreased lipid peroxidation level and the activities of glutathione peroxidase and glutathione-S-transferase (p<0.05), but it increased glutathione level and the activities of glutathione reductase, superoxide dismutase, and catalase in the renal tissues (p<0.05). The CFE- and PhA-treated rats with DM showed improved histochemical appearance and decreased abnormal glycogen accumulation. Therefore, we suggest that PhA-containing CFE could exert renal protective effects against STZ-induced oxidative stress.",

keywords = "Antioxidant enzyme, Capsosiphon fulvescens, Diabetic rats, Oxidative stress, Renal protective effects, Streptozotocin",

author = "Nam, {Mi Hyun} and Koo, {Yun Chang} and Hong, {Chung Oui} and Yang, {Sung Yong} and Kim, {Se Wook} and Jung, {Hye Lim} and Hwa Lee and Kim, {Ji Yeon} and Han, {Ah Ram} and Son, {Won Rak} and Pyo, {Min Cheol} and Lee, {Kwang Won}",

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AU - Nam, Mi Hyun

AU - Koo, Yun Chang

AU - Hong, Chung Oui

AU - Yang, Sung Yong

AU - Kim, Se Wook

AU - Jung, Hye Lim

AU - Lee, Hwa

AU - Kim, Ji Yeon

AU - Han, Ah Ram

AU - Son, Won Rak

AU - Pyo, Min Cheol

AU - Lee, Kwang Won

PY - 2014/10/1

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N2 - In this study, we evaluated the effect of Capsosiphon fulvescens extract (CFE) and its active compound, pheophorbide A (PhA), on diabetic kidney failure. Diabetes mellitus (DM) was induced by a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight (BW)). After a week, the rats were orally administered CFE (4 and 20 mg/ kg BW) or PhA (0.2 mg/kg BW) once a day for 9 weeks. After scarification, renal tissue samples were collected for biochemical and histochemical analyses. Our study showed that the treatment with CFE and PhA significantly decreased lipid peroxidation level and the activities of glutathione peroxidase and glutathione-S-transferase (p<0.05), but it increased glutathione level and the activities of glutathione reductase, superoxide dismutase, and catalase in the renal tissues (p<0.05). The CFE- and PhA-treated rats with DM showed improved histochemical appearance and decreased abnormal glycogen accumulation. Therefore, we suggest that PhA-containing CFE could exert renal protective effects against STZ-induced oxidative stress.

AB - In this study, we evaluated the effect of Capsosiphon fulvescens extract (CFE) and its active compound, pheophorbide A (PhA), on diabetic kidney failure. Diabetes mellitus (DM) was induced by a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg body weight (BW)). After a week, the rats were orally administered CFE (4 and 20 mg/ kg BW) or PhA (0.2 mg/kg BW) once a day for 9 weeks. After scarification, renal tissue samples were collected for biochemical and histochemical analyses. Our study showed that the treatment with CFE and PhA significantly decreased lipid peroxidation level and the activities of glutathione peroxidase and glutathione-S-transferase (p<0.05), but it increased glutathione level and the activities of glutathione reductase, superoxide dismutase, and catalase in the renal tissues (p<0.05). The CFE- and PhA-treated rats with DM showed improved histochemical appearance and decreased abnormal glycogen accumulation. Therefore, we suggest that PhA-containing CFE could exert renal protective effects against STZ-induced oxidative stress.

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KW - Capsosiphon fulvescens

KW - Diabetic rats

KW - Oxidative stress

KW - Renal protective effects

KW - Streptozotocin

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In vivo study of the renal protective effects of Capsosiphon fulvescens against streptozotocin-induced oxidative stress

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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