TY - JOUR
T1 - Increased corticomuscular coherence in idiopathic REM sleep behavior disorder
AU - Jung, Ki Young
AU - Cho, Jae Hyun
AU - Ko, Deokwon
AU - Seok, Hung Youl
AU - Yoon, Ho Kyoung
AU - Lee, Heon Jeong
AU - Kim, Leen
AU - Im, Chang Hwan
PY - 2012
Y1 - 2012
N2 - The authors hypothesized that if locomotor drive increases along with rapid eye movement (REM) sleep without atonia in idiopathic REM sleep behavior disorder (RBD), then RBD patients would have greater corticomuscular coherence (CMC) values during REM sleep than at other sleep stages and than in healthy control subjects during REM sleep. To explore this hypothesis, we analyzed beta frequency range CMC between sensorimo-tor cortex electroencephalography (EEG) and chin/limb muscle EMG in idiopathic RBD patients. Eleven drug naive idiopathic RBD patients and 11 age-matched healthy control subjects were included in the present study. All participants completed subjective sleep questionnaires and underwent polysomnography for one night. The CMC value between EEGs recorded at central electrodes and EMGs acquired at leg and chin muscles were computed and compared by repeated measures analysis of variance (ANOVA). Sleep stages and muscle (i.e., chin vs. leg) served as within-subject factors, and group served as the between-subject factor. Repeated measures ANOVA revealed no significant main effect of group (F-| 20 = 0.571, p = 0.458) ormuscle (F12o = 1.283, p = 0.271). However, sleep stage was found to have a significant main effect (F2.06741.332 =20.912, p< 0.001). The interaction between group and sleep stage was significant (F2.06741.332 = 3.438, p = 0.040). RBD patients had a significantly higher CMC value than controls during REM sleep (0.047 ± 0.00 vs. 0.052 ±0.00, respectively, p= 0.007). This study reveals increased CMC during REM sleep in patients with RBD, which indicates increased cortical locomotor drive. Furthermore, this study supports the hypothesis that sufficient locomotor drive plays a role in the pathophysiology of RBD in addition to REM sleep without atonia.
AB - The authors hypothesized that if locomotor drive increases along with rapid eye movement (REM) sleep without atonia in idiopathic REM sleep behavior disorder (RBD), then RBD patients would have greater corticomuscular coherence (CMC) values during REM sleep than at other sleep stages and than in healthy control subjects during REM sleep. To explore this hypothesis, we analyzed beta frequency range CMC between sensorimo-tor cortex electroencephalography (EEG) and chin/limb muscle EMG in idiopathic RBD patients. Eleven drug naive idiopathic RBD patients and 11 age-matched healthy control subjects were included in the present study. All participants completed subjective sleep questionnaires and underwent polysomnography for one night. The CMC value between EEGs recorded at central electrodes and EMGs acquired at leg and chin muscles were computed and compared by repeated measures analysis of variance (ANOVA). Sleep stages and muscle (i.e., chin vs. leg) served as within-subject factors, and group served as the between-subject factor. Repeated measures ANOVA revealed no significant main effect of group (F-| 20 = 0.571, p = 0.458) ormuscle (F12o = 1.283, p = 0.271). However, sleep stage was found to have a significant main effect (F2.06741.332 =20.912, p< 0.001). The interaction between group and sleep stage was significant (F2.06741.332 = 3.438, p = 0.040). RBD patients had a significantly higher CMC value than controls during REM sleep (0.047 ± 0.00 vs. 0.052 ±0.00, respectively, p= 0.007). This study reveals increased CMC during REM sleep in patients with RBD, which indicates increased cortical locomotor drive. Furthermore, this study supports the hypothesis that sufficient locomotor drive plays a role in the pathophysiology of RBD in addition to REM sleep without atonia.
KW - Corticomuscular coherence
KW - Pathophysiology
KW - REM sleep behavior disorder
KW - REM sleep without atonia
UR - http://www.scopus.com/inward/record.url?scp=84865847276&partnerID=8YFLogxK
U2 - 10.3389/fneur.2012.00060
DO - 10.3389/fneur.2012.00060
M3 - Article
C2 - 22536195
AN - SCOPUS:84865847276
SN - 1664-2295
VL - APR
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - Article 60
ER -