Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins

Min Jeong Shin; Patricia J. Blanche; Robin S. Rawlings; Harriett S. Fernstrom; Ronald M. Krauss

doi:10.1093/ajcn/85.6.1527

Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins

Min Jeong Shin
, Patricia J. Blanche
, Robin S. Rawlings
, Harriett S. Fernstrom
, Ronald M. Krauss^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Background: Low-fat, high-carbohydrate (LFHC) diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] and of triacylglycerol- rich lipoproteins (TRLs). Objective: We tested whether increases in plasma Lp(a) induced by an LFHC diet are related to changes in TRLs. Design: Healthy men (study 1; n = 140) consumed for 4 wk each a high-fat, low-carbohydrate diet (HFLC; 40% fat, 45% carbohydrate) and an LFHC diet (20% fat, 65% carbohydrate). Plasma lipids; lipoproteins; apolipoprotein (apo) B, A-I, and C-III; and Lp(a) were measured at the end of each diet. In a second group of men following a similar dietary protocol (study 2; n = 33), we isolated apo(a)-containing particles by immunoaffinity chromatography and determined the concentrations of apo C-III in ultracentrifugally isolated subfractions of apo B-containing lipoproteins. Results: In study 1, plasma concentrations of Lp(a) (P < 0.001), triacylglycerol (P < 0.001), apo B (P < 0.005), apo C-III (P < 0.005), and apo C-III in apo B-containing lipoproteins (non-HDL apo C-III) (P < 0.001) were significantly higher with the LFHC diet than with the HFLC diet. Stepwise multiple linear regression analysis showed that the association of changes in Lp(a) with changes in non-HDL apo C-III was independent of changes in body mass index, apo B, LDL cholesterol, and HDL cholesterol. Plasma lipid and lipoprotein changes were similar in study 2, and we found that both total apo C-III and the apo C-III content of apo(a)-containing particles were increased in a TRL fraction consisting predominantly of large VLDL particles [TRL-apo(a)]. Conclusions: The increase in plasma Lp(a) with an LFHC diet is significantly associated with an increase in non-HDL apo C-III. Enrichment of TRL-apo(a) with apo C-III may contribute to this dietary effect on Lp(a) concentrations.

Original language	English
Pages (from-to)	1527-1532
Number of pages	6
Journal	American Journal of Clinical Nutrition
Volume	85
Issue number	6
DOIs	https://doi.org/10.1093/ajcn/85.6.1527
Publication status	Published - 2007 Jun 1
Externally published	Yes

Bibliographical note

Funding Information:
The following funding is acknowledged: National Major Scientific Instruments and Equipment Development of NSFC (grant No. 11227902); National Natural Science Foundation of China (grant No. 11575284; grant No. 11475251; grant No. U1732268; grant No. 11705272).

Keywords

Apolipoprotein B
Apolipoprotein C-III
Dietary carbohydrate
Dietary fat
Lipoprotein(a)
Lp(a)

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

10.1093/ajcn/85.6.1527

Fingerprint

Dive into the research topics of 'Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins'. Together they form a unique fingerprint.

Cite this

Shin, M. J., Blanche, P. J., Rawlings, R. S., Fernstrom, H. S., & Krauss, R. M. (2007). Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins. American Journal of Clinical Nutrition, 85(6), 1527-1532. https://doi.org/10.1093/ajcn/85.6.1527

Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins. / Shin, Min Jeong; Blanche, Patricia J.; Rawlings, Robin S. et al.
In: American Journal of Clinical Nutrition, Vol. 85, No. 6, 01.06.2007, p. 1527-1532.

Research output: Contribution to journal › Article › peer-review

Shin, MJ, Blanche, PJ, Rawlings, RS, Fernstrom, HS & Krauss, RM 2007, 'Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins', American Journal of Clinical Nutrition, vol. 85, no. 6, pp. 1527-1532. https://doi.org/10.1093/ajcn/85.6.1527

Shin MJ, Blanche PJ, Rawlings RS, Fernstrom HS, Krauss RM. Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins. American Journal of Clinical Nutrition. 2007 Jun 1;85(6):1527-1532. doi: 10.1093/ajcn/85.6.1527

@article{e0d167a8a6364ca69a6d9b241e95fa49,

title = "Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins",

abstract = "Background: Low-fat, high-carbohydrate (LFHC) diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] and of triacylglycerol- rich lipoproteins (TRLs). Objective: We tested whether increases in plasma Lp(a) induced by an LFHC diet are related to changes in TRLs. Design: Healthy men (study 1; n = 140) consumed for 4 wk each a high-fat, low-carbohydrate diet (HFLC; 40\% fat, 45\% carbohydrate) and an LFHC diet (20\% fat, 65\% carbohydrate). Plasma lipids; lipoproteins; apolipoprotein (apo) B, A-I, and C-III; and Lp(a) were measured at the end of each diet. In a second group of men following a similar dietary protocol (study 2; n = 33), we isolated apo(a)-containing particles by immunoaffinity chromatography and determined the concentrations of apo C-III in ultracentrifugally isolated subfractions of apo B-containing lipoproteins. Results: In study 1, plasma concentrations of Lp(a) (P < 0.001), triacylglycerol (P < 0.001), apo B (P < 0.005), apo C-III (P < 0.005), and apo C-III in apo B-containing lipoproteins (non-HDL apo C-III) (P < 0.001) were significantly higher with the LFHC diet than with the HFLC diet. Stepwise multiple linear regression analysis showed that the association of changes in Lp(a) with changes in non-HDL apo C-III was independent of changes in body mass index, apo B, LDL cholesterol, and HDL cholesterol. Plasma lipid and lipoprotein changes were similar in study 2, and we found that both total apo C-III and the apo C-III content of apo(a)-containing particles were increased in a TRL fraction consisting predominantly of large VLDL particles [TRL-apo(a)]. Conclusions: The increase in plasma Lp(a) with an LFHC diet is significantly associated with an increase in non-HDL apo C-III. Enrichment of TRL-apo(a) with apo C-III may contribute to this dietary effect on Lp(a) concentrations.",

keywords = "Apolipoprotein B, Apolipoprotein C-III, Dietary carbohydrate, Dietary fat, Lipoprotein(a), Lp(a)",

author = "Shin, \{Min Jeong\} and Blanche, \{Patricia J.\} and Rawlings, \{Robin S.\} and Fernstrom, \{Harriett S.\} and Krauss, \{Ronald M.\}",

note = "Funding Information: The following funding is acknowledged: National Major Scientific Instruments and Equipment Development of NSFC (grant No. 11227902); National Natural Science Foundation of China (grant No. 11575284; grant No. 11475251; grant No. U1732268; grant No. 11705272).",

year = "2007",

month = jun,

day = "1",

doi = "10.1093/ajcn/85.6.1527",

language = "English",

volume = "85",

pages = "1527--1532",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins

AU - Shin, Min Jeong

AU - Blanche, Patricia J.

AU - Rawlings, Robin S.

AU - Fernstrom, Harriett S.

AU - Krauss, Ronald M.

N1 - Funding Information: The following funding is acknowledged: National Major Scientific Instruments and Equipment Development of NSFC (grant No. 11227902); National Natural Science Foundation of China (grant No. 11575284; grant No. 11475251; grant No. U1732268; grant No. 11705272).

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Background: Low-fat, high-carbohydrate (LFHC) diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] and of triacylglycerol- rich lipoproteins (TRLs). Objective: We tested whether increases in plasma Lp(a) induced by an LFHC diet are related to changes in TRLs. Design: Healthy men (study 1; n = 140) consumed for 4 wk each a high-fat, low-carbohydrate diet (HFLC; 40% fat, 45% carbohydrate) and an LFHC diet (20% fat, 65% carbohydrate). Plasma lipids; lipoproteins; apolipoprotein (apo) B, A-I, and C-III; and Lp(a) were measured at the end of each diet. In a second group of men following a similar dietary protocol (study 2; n = 33), we isolated apo(a)-containing particles by immunoaffinity chromatography and determined the concentrations of apo C-III in ultracentrifugally isolated subfractions of apo B-containing lipoproteins. Results: In study 1, plasma concentrations of Lp(a) (P < 0.001), triacylglycerol (P < 0.001), apo B (P < 0.005), apo C-III (P < 0.005), and apo C-III in apo B-containing lipoproteins (non-HDL apo C-III) (P < 0.001) were significantly higher with the LFHC diet than with the HFLC diet. Stepwise multiple linear regression analysis showed that the association of changes in Lp(a) with changes in non-HDL apo C-III was independent of changes in body mass index, apo B, LDL cholesterol, and HDL cholesterol. Plasma lipid and lipoprotein changes were similar in study 2, and we found that both total apo C-III and the apo C-III content of apo(a)-containing particles were increased in a TRL fraction consisting predominantly of large VLDL particles [TRL-apo(a)]. Conclusions: The increase in plasma Lp(a) with an LFHC diet is significantly associated with an increase in non-HDL apo C-III. Enrichment of TRL-apo(a) with apo C-III may contribute to this dietary effect on Lp(a) concentrations.

AB - Background: Low-fat, high-carbohydrate (LFHC) diets have been shown to increase plasma concentrations of lipoprotein(a) [Lp(a)] and of triacylglycerol- rich lipoproteins (TRLs). Objective: We tested whether increases in plasma Lp(a) induced by an LFHC diet are related to changes in TRLs. Design: Healthy men (study 1; n = 140) consumed for 4 wk each a high-fat, low-carbohydrate diet (HFLC; 40% fat, 45% carbohydrate) and an LFHC diet (20% fat, 65% carbohydrate). Plasma lipids; lipoproteins; apolipoprotein (apo) B, A-I, and C-III; and Lp(a) were measured at the end of each diet. In a second group of men following a similar dietary protocol (study 2; n = 33), we isolated apo(a)-containing particles by immunoaffinity chromatography and determined the concentrations of apo C-III in ultracentrifugally isolated subfractions of apo B-containing lipoproteins. Results: In study 1, plasma concentrations of Lp(a) (P < 0.001), triacylglycerol (P < 0.001), apo B (P < 0.005), apo C-III (P < 0.005), and apo C-III in apo B-containing lipoproteins (non-HDL apo C-III) (P < 0.001) were significantly higher with the LFHC diet than with the HFLC diet. Stepwise multiple linear regression analysis showed that the association of changes in Lp(a) with changes in non-HDL apo C-III was independent of changes in body mass index, apo B, LDL cholesterol, and HDL cholesterol. Plasma lipid and lipoprotein changes were similar in study 2, and we found that both total apo C-III and the apo C-III content of apo(a)-containing particles were increased in a TRL fraction consisting predominantly of large VLDL particles [TRL-apo(a)]. Conclusions: The increase in plasma Lp(a) with an LFHC diet is significantly associated with an increase in non-HDL apo C-III. Enrichment of TRL-apo(a) with apo C-III may contribute to this dietary effect on Lp(a) concentrations.

KW - Apolipoprotein B

KW - Apolipoprotein C-III

KW - Dietary carbohydrate

KW - Dietary fat

KW - Lipoprotein(a)

KW - Lp(a)

UR - https://www.scopus.com/pages/publications/34250024908

U2 - 10.1093/ajcn/85.6.1527

DO - 10.1093/ajcn/85.6.1527

M3 - Article

C2 - 17556688

AN - SCOPUS:34250024908

SN - 0002-9165

VL - 85

SP - 1527

EP - 1532

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 6

ER -

Increased plasma concentrations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this