Increased shikonin production by hairy roots of Lithospermum erythrorhizon in two phase bubble column reactor

Sang Jun Sim, Ho Nam Chang

    Research output: Contribution to journalArticlepeer-review

    43 Citations (Scopus)

    Abstract

    Plant hairy root cultures of Lithospermum erythrorhizon were carried out to produce shikonin derivatives by employing in situ extraction with n-hexadecane in a shake flask and a bubble column bioreactor. Over 95 % shikonin produced was recovered in the n-hexadecane layer. In flask cultures the maximum concentration of shikonin with n-hexadecane extraction was 3 times higher than that obtained without extraction. In the two phase bubble column reactor, 572.6 mg/L of shikonin and 15.6 g/L of dry cell mass were obtained after 54 days. Shikonin was produced at a constant level of 10.6 mg/L day during this period.

    Original languageEnglish
    Pages (from-to)145-150
    Number of pages6
    JournalBiotechnology letters
    Volume15
    Issue number2
    DOIs
    Publication statusPublished - 1993 Feb

    ASJC Scopus subject areas

    • Biotechnology
    • Bioengineering
    • Applied Microbiology and Biotechnology

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