Increases in spinal vasoactive intestinal polypeptide and neuropeptide Y are not sufficient for the genesis of neuropathic pain in rats

Hee Jin Kim, Seung Keun Back, Junesun Kim, Backil Sung, Seung Kil Hong, Heung Sik Na

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We tested the hypothesis that increases in the spinal levels of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were related to the development of neuropathic pain. To this aim, we compared two groups of rats. One group showed well-developed neuropathic pain in the tail following unilateral transection of the inferior and superior caudal trunks between the S1 and S2 spinal nerves, and the other group showed poorly-developed neuropathic pain despite the same nerve injury. The increases in immunoreactivity of VIP and NPY in the S1 dorsal horn (injured segment) were not significantly different between the two groups. These results suggested that increases in the spinal levels of VIP and NPY after peripheral nerve injury were not sufficient for the development of neuropathic pain.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalNeuroscience Letters
Volume342
Issue number1-2
DOIs
Publication statusPublished - 2003 May 15

Bibliographical note

Funding Information:
This study was supported by Brain Korea 21 Project in 2002, the Ministry of Education and a grant of the Ministry of Health and Welfare (01-PJ8-PG3-21302-0004).

Keywords

  • Allodynia
  • Dorsal horn
  • Neuropathic pain
  • Neuropeptide Y
  • Peripheral neuropathy
  • Vasoactive polypeptide

ASJC Scopus subject areas

  • General Neuroscience

Fingerprint

Dive into the research topics of 'Increases in spinal vasoactive intestinal polypeptide and neuropeptide Y are not sufficient for the genesis of neuropathic pain in rats'. Together they form a unique fingerprint.

Cite this