Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

Joo Hee Jang, Hoyeon Lee, Amit Sharma, Sang Min Lee, Tae Hoon Lee, Chulhun Kang, Jong Seung Kim

    Research output: Contribution to journalArticlepeer-review

    43 Citations (Scopus)

    Abstract

    An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.

    Original languageEnglish
    Pages (from-to)9965-9968
    Number of pages4
    JournalChemical Communications
    Volume52
    Issue number64
    DOIs
    Publication statusPublished - 2016

    Bibliographical note

    Publisher Copyright:
    © 2016 The Royal Society of Chemistry.

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Catalysis
    • Ceramics and Composites
    • General Chemistry
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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