Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

Joo Hee Jang; Hoyeon Lee; Amit Sharma; Sang Min Lee; Tae Hoon Lee; Chulhun Kang; Jong Seung Kim

doi:10.1039/c6cc04255d

Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

Joo Hee Jang, Hoyeon Lee, Amit Sharma, Sang Min Lee, Tae Hoon Lee, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.

Original language	English
Pages (from-to)	9965-9968
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	64
DOIs	https://doi.org/10.1039/c6cc04255d
Publication status	Published - 2016

Bibliographical note

Funding Information:
This work was supported by CRI (No. 2009-0081566, JSK), NRF (No. 2015R1A5A1037656, CK), the Basic Science Research Program (No. 20100020209, CK) project grants fromthe National Research Foundation of Korea.

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c6cc04255d

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title = "Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease",

abstract = "An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.",

author = "Jang, {Joo Hee} and Hoyeon Lee and Amit Sharma and Lee, {Sang Min} and Lee, {Tae Hoon} and Chulhun Kang and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by CRI (No. 2009-0081566, JSK), NRF (No. 2015R1A5A1037656, CK), the Basic Science Research Program (No. 20100020209, CK) project grants fromthe National Research Foundation of Korea. Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

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language = "English",

volume = "52",

pages = "9965--9968",

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T1 - Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

AU - Jang, Joo Hee

AU - Lee, Hoyeon

AU - Sharma, Amit

AU - Lee, Sang Min

AU - Lee, Tae Hoon

AU - Kang, Chulhun

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by CRI (No. 2009-0081566, JSK), NRF (No. 2015R1A5A1037656, CK), the Basic Science Research Program (No. 20100020209, CK) project grants fromthe National Research Foundation of Korea. Publisher Copyright: © 2016 The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.

AB - An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin's role in designing new cancer-specific drug delivery frameworks.

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SN - 1359-7345

VL - 52

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EP - 9968

JO - Chemical Communications

JF - Chemical Communications

IS - 64

ER -

Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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