Inducing rapid cellular response on RGD-binding threaded macromolecular surfaces

Ji Hun Seo, Sachiro Kakinoki, Yuuki Inoue, Tetsuji Yamaoka, Kazuhiko Ishihara, Nobuhiko Yui

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)


The rapid response of integrin β1 molecules to an RGD peptide on a dynamic polyrotaxane surface was successfully induced. As a result, RGD peptides introduced on a highly dynamic cyclodextrin molecule enhanced the frequency of contact with specific integrin molecules on the cell membrane at the early stage of material-cell interactions.

Original languageEnglish
Pages (from-to)5513-5516
Number of pages4
JournalJournal of the American Chemical Society
Issue number15
Publication statusPublished - 2013 Apr 17
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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