Induction of CITED2 expression in the rat hippocampus following transient global ischemia

Woong Sun; Kye Hyun Kim; Mira Noh; Soontaek Hong; Pil Woo Huh; Younghwa Kim; Hyun Kim

doi:10.1016/j.brainres.2005.12.016

Induction of CITED2 expression in the rat hippocampus following transient global ischemia

Woong Sun, Kye Hyun Kim, Mira Noh, Soontaek Hong, Pil Woo Huh, Younghwa Kim, Hyun Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

CITED2 is implicated in the modulating the activity of HIF-1 which is a major transcription factor involved in ischemia-related gene expression. Following transient forebrain ischemia, we found that CITED2 was induced in a subset of brain regions including dentate gyrus of the hippocampal formation and piriform cortex. Because CITED2 was not induced in cultured neurons exposed to oxygen-glucose deprivation, we concluded that hypoxia is not sufficient to trigger its induction.

Original language	English
Pages (from-to)	15-18
Number of pages	4
Journal	Brain Research
Volume	1072
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2005.12.016
Publication status	Published - 2006 Feb 9

Keywords

CITED2
Dentate gyrus
Gene expression
HIF-1
Transient forebrain ischemia

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2005.12.016

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title = "Induction of CITED2 expression in the rat hippocampus following transient global ischemia",

abstract = "CITED2 is implicated in the modulating the activity of HIF-1 which is a major transcription factor involved in ischemia-related gene expression. Following transient forebrain ischemia, we found that CITED2 was induced in a subset of brain regions including dentate gyrus of the hippocampal formation and piriform cortex. Because CITED2 was not induced in cultured neurons exposed to oxygen-glucose deprivation, we concluded that hypoxia is not sufficient to trigger its induction.",

keywords = "CITED2, Dentate gyrus, Gene expression, HIF-1, Transient forebrain ischemia",

author = "Woong Sun and Kim, {Kye Hyun} and Mira Noh and Soontaek Hong and Huh, {Pil Woo} and Younghwa Kim and Hyun Kim",

note = "Funding Information: This work was supported by grant of Korean Ministry of Health and Welfare (02-PJ1-PG1-CH06-0001) and Korea Science and Engineering Foundation (M1050000004905J000004910). A part of this work was technically supported by the core facility service of the 21C Frontier Brain Research Center.",

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doi = "10.1016/j.brainres.2005.12.016",

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AU - Sun, Woong

AU - Kim, Kye Hyun

AU - Noh, Mira

AU - Hong, Soontaek

AU - Huh, Pil Woo

AU - Kim, Younghwa

AU - Kim, Hyun

N1 - Funding Information: This work was supported by grant of Korean Ministry of Health and Welfare (02-PJ1-PG1-CH06-0001) and Korea Science and Engineering Foundation (M1050000004905J000004910). A part of this work was technically supported by the core facility service of the 21C Frontier Brain Research Center.

PY - 2006/2/9

Y1 - 2006/2/9

N2 - CITED2 is implicated in the modulating the activity of HIF-1 which is a major transcription factor involved in ischemia-related gene expression. Following transient forebrain ischemia, we found that CITED2 was induced in a subset of brain regions including dentate gyrus of the hippocampal formation and piriform cortex. Because CITED2 was not induced in cultured neurons exposed to oxygen-glucose deprivation, we concluded that hypoxia is not sufficient to trigger its induction.

AB - CITED2 is implicated in the modulating the activity of HIF-1 which is a major transcription factor involved in ischemia-related gene expression. Following transient forebrain ischemia, we found that CITED2 was induced in a subset of brain regions including dentate gyrus of the hippocampal formation and piriform cortex. Because CITED2 was not induced in cultured neurons exposed to oxygen-glucose deprivation, we concluded that hypoxia is not sufficient to trigger its induction.

KW - CITED2

KW - Dentate gyrus

KW - Gene expression

KW - HIF-1

KW - Transient forebrain ischemia

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Induction of CITED2 expression in the rat hippocampus following transient global ischemia

Abstract

Keywords

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