Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation

In Duk Jung; Jun Sik Lee; Chang Min Lee; Kyung Tae Noh; Yeong Il Jeong; Won Sun Park; Sung Hak Chun; Soo Kyung Jeong; Jin Wook Park; Kwang Hee Son; Deok Rim Heo; Min Goo Lee; Yong Kyoo Shin; Han Wool Kim; Cheol Heui Yun; Yeong Min Park

doi:10.1016/j.bcp.2010.04.025

Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation

In Duk Jung, Jun Sik Lee, Chang Min Lee, Kyung Tae Noh, Yeong Il Jeong, Won Sun Park, Sung Hak Chun, Soo Kyung Jeong, Jin Wook Park, Kwang Hee Son, Deok Rim Heo, Min Goo Lee, Yong Kyoo Shin, Han Wool Kim, Cheol Heui Yun, Yeong Min Park

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23 Citations (Scopus)

Abstract

Heme oxygenase (HO)-1 is expressed in a variety of conditions involved in the regulation of immune responses. In this study, we examined the role of HO-1 in dendritic cell (DC) maturation and expression of indoleamine 2,3-dioxygenase (IDO), a key enzyme that catalyzes the initial, rate-limiting step in tryptophan degradation. IDO deficiency led to diminished phenotypic and functional maturation of DCs in vitro and in vivo. IDO expression and DC maturation was abrogated by the HO inhibitor zinc protoporphrin, but increased by hemin, a potent inducer of HO-1. Moreover, LPS-induced HO-1 expression was mediated by an NF-κB-dependent pathway. Our findings provide additional insight into the immunological functions of IDO and HO-1, and suggest possible therapeutic adjuvants for the treatment of DC-related acute and chronic diseases.

Original language	English
Pages (from-to)	491-505
Number of pages	15
Journal	Biochemical Pharmacology
Volume	80
Issue number	4
DOIs	https://doi.org/10.1016/j.bcp.2010.04.025
Publication status	Published - 2010 Aug
Externally published	Yes

Keywords

Dendritic cells
Heme oxygenase
Indoleamine 2,3-dioxygenase
Lipopolysaccharide

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/j.bcp.2010.04.025

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Jung, I. D., Lee, J. S., Lee, C. M., Noh, K. T., Jeong, Y. I., Park, W. S., Chun, S. H., Jeong, S. K., Park, J. W., Son, K. H., Heo, D. R., Lee, M. G., Shin, Y. K., Kim, H. W., Yun, C. H., & Park, Y. M. (2010). Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation. Biochemical Pharmacology, 80(4), 491-505. https://doi.org/10.1016/j.bcp.2010.04.025

Jung, ID, Lee, JS, Lee, CM, Noh, KT, Jeong, YI, Park, WS, Chun, SH, Jeong, SK, Park, JW, Son, KH, Heo, DR, Lee, MG, Shin, YK, Kim, HW, Yun, CH & Park, YM 2010, 'Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation', Biochemical Pharmacology, vol. 80, no. 4, pp. 491-505. https://doi.org/10.1016/j.bcp.2010.04.025

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title = "Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation",

abstract = "Heme oxygenase (HO)-1 is expressed in a variety of conditions involved in the regulation of immune responses. In this study, we examined the role of HO-1 in dendritic cell (DC) maturation and expression of indoleamine 2,3-dioxygenase (IDO), a key enzyme that catalyzes the initial, rate-limiting step in tryptophan degradation. IDO deficiency led to diminished phenotypic and functional maturation of DCs in vitro and in vivo. IDO expression and DC maturation was abrogated by the HO inhibitor zinc protoporphrin, but increased by hemin, a potent inducer of HO-1. Moreover, LPS-induced HO-1 expression was mediated by an NF-κB-dependent pathway. Our findings provide additional insight into the immunological functions of IDO and HO-1, and suggest possible therapeutic adjuvants for the treatment of DC-related acute and chronic diseases.",

keywords = "Dendritic cells, Heme oxygenase, Indoleamine 2,3-dioxygenase, Lipopolysaccharide",

author = "Jung, {In Duk} and Lee, {Jun Sik} and Lee, {Chang Min} and Noh, {Kyung Tae} and Jeong, {Yeong Il} and Park, {Won Sun} and Chun, {Sung Hak} and Jeong, {Soo Kyung} and Park, {Jin Wook} and Son, {Kwang Hee} and Heo, {Deok Rim} and Lee, {Min Goo} and Shin, {Yong Kyoo} and Kim, {Han Wool} and Yun, {Cheol Heui} and Park, {Yeong Min}",

note = "Funding Information: This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Repubilc of Korea ( A091047 ). ",

year = "2010",

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doi = "10.1016/j.bcp.2010.04.025",

language = "English",

volume = "80",

pages = "491--505",

journal = "Biochemical Pharmacology",

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T1 - Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation

AU - Jung, In Duk

AU - Lee, Jun Sik

AU - Lee, Chang Min

AU - Noh, Kyung Tae

AU - Jeong, Yeong Il

AU - Park, Won Sun

AU - Chun, Sung Hak

AU - Jeong, Soo Kyung

AU - Park, Jin Wook

AU - Son, Kwang Hee

AU - Heo, Deok Rim

AU - Lee, Min Goo

AU - Shin, Yong Kyoo

AU - Kim, Han Wool

AU - Yun, Cheol Heui

AU - Park, Yeong Min

N1 - Funding Information: This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Repubilc of Korea ( A091047 ).

PY - 2010/8

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N2 - Heme oxygenase (HO)-1 is expressed in a variety of conditions involved in the regulation of immune responses. In this study, we examined the role of HO-1 in dendritic cell (DC) maturation and expression of indoleamine 2,3-dioxygenase (IDO), a key enzyme that catalyzes the initial, rate-limiting step in tryptophan degradation. IDO deficiency led to diminished phenotypic and functional maturation of DCs in vitro and in vivo. IDO expression and DC maturation was abrogated by the HO inhibitor zinc protoporphrin, but increased by hemin, a potent inducer of HO-1. Moreover, LPS-induced HO-1 expression was mediated by an NF-κB-dependent pathway. Our findings provide additional insight into the immunological functions of IDO and HO-1, and suggest possible therapeutic adjuvants for the treatment of DC-related acute and chronic diseases.

AB - Heme oxygenase (HO)-1 is expressed in a variety of conditions involved in the regulation of immune responses. In this study, we examined the role of HO-1 in dendritic cell (DC) maturation and expression of indoleamine 2,3-dioxygenase (IDO), a key enzyme that catalyzes the initial, rate-limiting step in tryptophan degradation. IDO deficiency led to diminished phenotypic and functional maturation of DCs in vitro and in vivo. IDO expression and DC maturation was abrogated by the HO inhibitor zinc protoporphrin, but increased by hemin, a potent inducer of HO-1. Moreover, LPS-induced HO-1 expression was mediated by an NF-κB-dependent pathway. Our findings provide additional insight into the immunological functions of IDO and HO-1, and suggest possible therapeutic adjuvants for the treatment of DC-related acute and chronic diseases.

KW - Dendritic cells

KW - Heme oxygenase

KW - Indoleamine 2,3-dioxygenase

KW - Lipopolysaccharide

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Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation

Abstract

Keywords

ASJC Scopus subject areas

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