Influence of anti-adhesive agent on incidence of bile leakage after liver resection: A prospective cohort study

Young Dong Yu, Dong Sik Kim, Sung Won Jung, Jae Hyun Han, Sung Ock Suh

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background: Anti-adhesive agents are increasingly used to reduce the incidence of postoperative adhesions following abdominal surgery. Bile leakage after liver resection remains a major cause of postoperative morbidity. The aim of this study was to examine the effect of anti-adhesive agent on bile leakage after liver resection. Materials and methods: 77 patients were enrolled to receive an anti-adhesive agent (study group) during liver resection between May 2012 and August 2013. The study group was compared to a match-paired control group. Clinical data were collected including bilirubin concentration in serum and drain fluid and bile leakage rate. In addition, a separate analysis was performed between patients with and without postoperative bile leakage. Results: There was no difference in bile leakage rate or hospital stay between the study group (n = 77) and control group (n = 77). Of the total number of patients (n = 154), there were 29 patients with postoperative bile leak and 125 patients without bile leak. On univariate analysis, patients without history of hepatitis were significantly associated with bile leakage. In addition, liver resection with broader cut surface area was associated with bile leakage. Application of anti-adhesive agent was not associated with bile leakage. On multivariate analysis, resection with broader cut surface area (OR = 2.788, p = 0.026) and patients without history of hepatitis (OR = 5.153, p = 0.039) were significantly associated with bile leakage. Conclusions: Larger area of cut-surface and patients without history of hepatitis were significant risk factors for bile leakage. The use of anti-adhesive agent was not associated with increased risk of bile leakage.

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalInternational Journal of Surgery
Volume31
DOIs
Publication statusPublished - 2016 Jul 1
Externally publishedYes

Bibliographical note

Funding Information:
This investigator initiated study was funded by the Hanmi Pharmaceutical Company (Hanmi tower, Songpagu Bangyidong, Seoul, Korea).

Publisher Copyright:
© 2016 IJS Publishing Group Ltd.

Keywords

  • Anti-adhesive agent
  • Bile leakage
  • Liver resection

ASJC Scopus subject areas

  • General Medicine

Fingerprint

Dive into the research topics of 'Influence of anti-adhesive agent on incidence of bile leakage after liver resection: A prospective cohort study'. Together they form a unique fingerprint.

Cite this