Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder

Eunsoo Won; June Kang; Aram Kim; Sunyoung Choi; Kyu Man Han; Woo Suk Tae; Hun Soo Chang; Kyu Ri Son; Tsafrir Greenberg; Sook Haeng Joe; Min Soo Lee; Byung Joo Ham

doi:10.1016/j.psyneuen.2016.07.008

Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder

Eunsoo Won, June Kang, Aram Kim, Sunyoung Choi, Kyu Man Han, Woo Suk Tae, Hun Soo Chang, Kyu Ri Son, Tsafrir Greenberg, Sook Haeng Joe, Min Soo Lee, Byung Joo Ham

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.

Original language	English
Pages (from-to)	147-155
Number of pages	9
Journal	Psychoneuroendocrinology
Volume	72
DOIs	https://doi.org/10.1016/j.psyneuen.2016.07.008
Publication status	Published - 2016 Oct 1

Keywords

BclI C/G (rs41423247)
Hippocampus
Major depressive disorder
Parahippocampal cingulum

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psyneuen.2016.07.008

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Won, E., Kang, J., Kim, A., Choi, S., Han, K. M., Tae, W. S., Chang, H. S., Son, K. R., Greenberg, T., Joe, S. H., Lee, M. S., & Ham, B. J. (2016). Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder. Psychoneuroendocrinology, 72, 147-155. https://doi.org/10.1016/j.psyneuen.2016.07.008

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title = "Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder",

abstract = "We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.",

keywords = "BclI C/G (rs41423247), Hippocampus, Major depressive disorder, Parahippocampal cingulum",

author = "Eunsoo Won and June Kang and Aram Kim and Sunyoung Choi and Han, {Kyu Man} and Tae, {Woo Suk} and Chang, {Hun Soo} and Son, {Kyu Ri} and Tsafrir Greenberg and Joe, {Sook Haeng} and Lee, {Min Soo} and Ham, {Byung Joo}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Education , Science and Technology ( NRF-2014R1A1A2058864 ). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.psyneuen.2016.07.008",

language = "English",

volume = "72",

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journal = "Psychoneuroendocrinology",

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T1 - Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder

AU - Won, Eunsoo

AU - Kang, June

AU - Kim, Aram

AU - Choi, Sunyoung

AU - Han, Kyu Man

AU - Tae, Woo Suk

AU - Chang, Hun Soo

AU - Son, Kyu Ri

AU - Greenberg, Tsafrir

AU - Joe, Sook Haeng

AU - Lee, Min Soo

AU - Ham, Byung Joo

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Education , Science and Technology ( NRF-2014R1A1A2058864 ). Publisher Copyright: © 2016 Elsevier Ltd

PY - 2016/10/1

Y1 - 2016/10/1

N2 - We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.

AB - We investigated the interactive effects of BclI C/G (rs41423247) allelic variants and the diagnosis of major depressive disorder (MDD) on hippocampal shape and integrity of the left parahippocampal subdivision of the cingulum. Fifty-two patients with MDD and 52 healthy controls (HCs) underwent T1-weighted structural magnetic resonance imaging and BclI C/G (rs41423247) genotyping. We analyzed hippocampal shape using the FIRST module of FSL and analyzed white matter (WM) integrity using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). Significant alterations in left hippocampal shape and decreased fractional anisotropy (FA) values of the left parahippocampal cingulum were observed in MDD patients, compared to HCs. In addition, MDD patients of the BclI minor (G-) allele carrier group showed significant alterations in left hippocampal shape and decreased FA values of the left parahippocampal cingulum compared to BclI minor (G-) allele carrier HCs. No significant differences between diagnostic subgroups of the C/C homozygotes were observed. Our study provides evidence for alterations in hippocampal shape and decreased integrity of the WM region associated with the hippocampus in MDD, and for the possible influence of BclI C/G polymorphism (rs41423247) on hippocampal shape and integrity of the parahippocampal subdivision of the cingulum in depression.

KW - BclI C/G (rs41423247)

KW - Hippocampus

KW - Major depressive disorder

KW - Parahippocampal cingulum

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U2 - 10.1016/j.psyneuen.2016.07.008

DO - 10.1016/j.psyneuen.2016.07.008

M3 - Article

C2 - 27428087

AN - SCOPUS:84978191176

SN - 0306-4530

VL - 72

SP - 147

EP - 155

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

ER -

Influence of BclI C/G (rs41423247) on hippocampal shape and white matter integrity of the parahippocampal cingulum in major depressive disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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