Influence of BDNF variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia

Chi Un Pae, Alberto Chiesa, Stefano Porcelli, Changsu Han, Ashwin A. Patkar, Soo Jung Lee, Moon Ho Park, Alessandro Serretti, Diana De Ronchi

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Aim: The present study aimed to explore whether some single nucleotide polymorphisms (SNPs) within the BDNF gene could be associated with major depression (MD), bipolar disorder (BD) and schizophrenia, and whether they could predict clinical outcomes in Korean inpatients treated with antidepressants, mood stabilizers and antipsychotics, respectively. Methods: One hundred and forty-five patients with MD, 132 patients with BD, 221 patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for 5 BDNF SNPs (rs2030324, rs7103873, rs10835210, rs11030101 and rs6265). Baseline and final clinical measures - including the Montgomery-Asberg Depression Rating Scale, Young Mania Rating Scale and Positive and Negative Symptoms Scale for patients with MD, BD and schizophrenia, respectively - were recorded. Results: rs10835210 CA and rs11030101 AT genotype frequencies were higher in BD and schizophrenia patients than in healthy and MD subjects. No significant association was found with clinical improvement. Discussion: Our findings provide evidence of an association between BDNF and BD and schizophrenia. However, taking into account the several limitations of our study, including the moderately small sample size, further research is needed to draw more definitive conclusions.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalNeuropsychobiology
Volume65
Issue number1
DOIs
Publication statusPublished - 2011 Dec
Externally publishedYes

Bibliographical note

Funding Information:
The authors gratefully acknowledge the financial support of the National Natural Science Foundation of China [Grants 51374213 and 51674251], National Natural Science Fund for Distinguished Young Scholars of China [Grant 51125017], Science Fund for Creative Research Groups of the National Natural Science Foundation of China [Grant 51421003], Fund for Creative Research and Development Group Program of Jiangsu Province [Grant 2014-27], and the Priority Academic Program Development of Jiangsu Higher Education Institutions (Grant PAPD2014). The authors would also like to express their gratitude to the editors and the anonymous reviewers for their valuable comments and suggestions, which have greatly improved this paper.

Keywords

  • BDNF
  • Bipolar disorder
  • Brain-derived neurotrophic factor
  • Major depression
  • Schizophrenia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

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