Abstract
Chitosan-coated nanoliposomes containing etofenprox or alpha-cypermethrin prepared by ultrasonic homogenization maintained a size distribution in the nanometre range. Nanoliposomes were constructed using different types and concentrations of chitosan to regulate the mean size and surface charge. As the chitosan concentration (0.10.5%, w/v) and the degree of deacetylation increased, surface charge also increased. The encapsulation efficiency and release profile were measured by gas chromatography. Encapsulation efficiency decreased slightly as chitosan concentration increased (0.10.5%, w/v). As the intrinsic surface charge or concentration of the coating material increased, the release period of the entrapped core material was extended (chitosans A and B; 0.1 and 0.3%, w/v). The results indicate that diverse preparation conditions could affect the physicochemical properties and release profile of the resulting nanocarrier systems.
Original language | English |
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Pages (from-to) | 595-604 |
Number of pages | 10 |
Journal | Journal of Microencapsulation |
Volume | 28 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2011 Nov |
Bibliographical note
Funding Information:This study was supported by a grant from the Ministry of Agriculture and Forestry project, Republic of Korea.
Keywords
- Chitosan
- Chitosan-coated liposome
- Controlled release
- Nanocarrier system
- Phosphatidylcholine
- Self-assembly
ASJC Scopus subject areas
- Bioengineering
- Pharmaceutical Science
- Physical and Theoretical Chemistry
- Organic Chemistry
- Colloid and Surface Chemistry