Abstract
The present study is aimed to exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with major depressive disorder (MDD) and whether they could predict clinical outcomes in Korean in-patients, respectively, treated with antidepressants. One hundred forty-five (145) patients with MDD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale (MADRS) for patients with MDD, were recorded.No association was observed between alleles, genotypes and haplotypes under investigation and clinical and demographical variables. As a secondary finding, a marginal association was observed between rs4302506 and rs4403097 alleles within GRIA2 and age of onset in patients with MDD. Our findings provide evidence for a possible association between rs4302506 and rs4403097 SNPs and age of onset in patients withMDD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions.
Original language | English |
---|---|
Pages (from-to) | 305-311 |
Number of pages | 7 |
Journal | European Archives of Psychiatry and Clinical Neuroscience |
Volume | 262 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2012 Jun |
Externally published | Yes |
Bibliographical note
Funding Information:Acknowledgment This study was supported by a grant of the Korean Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).
Keywords
- GRIA1
- GRIA2
- GRIA4
- Major depressive disorder
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Pharmacology (medical)