Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder

Alberto Chiesa; Concetta Crisafulli; Stefano Porcelli; Changsu Han; Ashwin A. Patkar; Soo Jung Lee; Moon Ho Park; Tae Youn Jun; Alessandro Serretti; Chi Un Pae

doi:10.1007/s00406-011-0270-y

Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder

Alberto Chiesa, Concetta Crisafulli, Stefano Porcelli, Changsu Han, Ashwin A. Patkar, Soo Jung Lee, Moon Ho Park, Tae Youn Jun, Alessandro Serretti, Chi Un Pae

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The present study is aimed to exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with major depressive disorder (MDD) and whether they could predict clinical outcomes in Korean in-patients, respectively, treated with antidepressants. One hundred forty-five (145) patients with MDD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale (MADRS) for patients with MDD, were recorded.No association was observed between alleles, genotypes and haplotypes under investigation and clinical and demographical variables. As a secondary finding, a marginal association was observed between rs4302506 and rs4403097 alleles within GRIA2 and age of onset in patients with MDD. Our findings provide evidence for a possible association between rs4302506 and rs4403097 SNPs and age of onset in patients withMDD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions.

Original language	English
Pages (from-to)	305-311
Number of pages	7
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	262
Issue number	4
DOIs	https://doi.org/10.1007/s00406-011-0270-y
Publication status	Published - 2012 Jun
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgment This study was supported by a grant of the Korean Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).

Keywords

GRIA1
GRIA2
GRIA4
Major depressive disorder

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00406-011-0270-y

Cite this

Chiesa, A., Crisafulli, C., Porcelli, S., Han, C., Patkar, A. A., Lee, S. J., Park, M. H., Jun, T. Y., Serretti, A., & Pae, C. U. (2012). Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder. European Archives of Psychiatry and Clinical Neuroscience, 262(4), 305-311. https://doi.org/10.1007/s00406-011-0270-y

Chiesa, A, Crisafulli, C, Porcelli, S, Han, C, Patkar, AA, Lee, SJ, Park, MH, Jun, TY, Serretti, A & Pae, CU 2012, 'Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder', European Archives of Psychiatry and Clinical Neuroscience, vol. 262, no. 4, pp. 305-311. https://doi.org/10.1007/s00406-011-0270-y

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abstract = "The present study is aimed to exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with major depressive disorder (MDD) and whether they could predict clinical outcomes in Korean in-patients, respectively, treated with antidepressants. One hundred forty-five (145) patients with MDD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale (MADRS) for patients with MDD, were recorded.No association was observed between alleles, genotypes and haplotypes under investigation and clinical and demographical variables. As a secondary finding, a marginal association was observed between rs4302506 and rs4403097 alleles within GRIA2 and age of onset in patients with MDD. Our findings provide evidence for a possible association between rs4302506 and rs4403097 SNPs and age of onset in patients withMDD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions.",

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AU - Crisafulli, Concetta

AU - Porcelli, Stefano

AU - Han, Changsu

AU - Patkar, Ashwin A.

AU - Lee, Soo Jung

AU - Park, Moon Ho

AU - Jun, Tae Youn

AU - Serretti, Alessandro

AU - Pae, Chi Un

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AB - The present study is aimed to exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with major depressive disorder (MDD) and whether they could predict clinical outcomes in Korean in-patients, respectively, treated with antidepressants. One hundred forty-five (145) patients with MDD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale (MADRS) for patients with MDD, were recorded.No association was observed between alleles, genotypes and haplotypes under investigation and clinical and demographical variables. As a secondary finding, a marginal association was observed between rs4302506 and rs4403097 alleles within GRIA2 and age of onset in patients with MDD. Our findings provide evidence for a possible association between rs4302506 and rs4403097 SNPs and age of onset in patients withMDD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions.

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Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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