TY - JOUR
T1 - Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorder
AU - Chiesa, Alberto
AU - Crisafulli, Concetta
AU - Porcelli, Stefano
AU - Han, Changsu
AU - Patkar, Ashwin A.
AU - Lee, Soo Jung
AU - Park, Moon Ho
AU - Jun, Tae Youn
AU - Serretti, Alessandro
AU - Pae, Chi Un
N1 - Funding Information:
Acknowledgment This study was supported by a grant of the Korean Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).
PY - 2012/6
Y1 - 2012/6
N2 - The present study is aimed to exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with major depressive disorder (MDD) and whether they could predict clinical outcomes in Korean in-patients, respectively, treated with antidepressants. One hundred forty-five (145) patients with MDD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale (MADRS) for patients with MDD, were recorded.No association was observed between alleles, genotypes and haplotypes under investigation and clinical and demographical variables. As a secondary finding, a marginal association was observed between rs4302506 and rs4403097 alleles within GRIA2 and age of onset in patients with MDD. Our findings provide evidence for a possible association between rs4302506 and rs4403097 SNPs and age of onset in patients withMDD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions.
AB - The present study is aimed to exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with major depressive disorder (MDD) and whether they could predict clinical outcomes in Korean in-patients, respectively, treated with antidepressants. One hundred forty-five (145) patients with MDD and 170 healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale (MADRS) for patients with MDD, were recorded.No association was observed between alleles, genotypes and haplotypes under investigation and clinical and demographical variables. As a secondary finding, a marginal association was observed between rs4302506 and rs4403097 alleles within GRIA2 and age of onset in patients with MDD. Our findings provide evidence for a possible association between rs4302506 and rs4403097 SNPs and age of onset in patients withMDD. However, taking into account that the several limitations of our study including the moderately small sample size of our study, our findings should be considered with caution and further research is needed to draw more definitive conclusions.
KW - GRIA1
KW - GRIA2
KW - GRIA4
KW - Major depressive disorder
UR - http://www.scopus.com/inward/record.url?scp=84864927226&partnerID=8YFLogxK
U2 - 10.1007/s00406-011-0270-y
DO - 10.1007/s00406-011-0270-y
M3 - Article
C2 - 22057216
AN - SCOPUS:84864927226
SN - 0940-1334
VL - 262
SP - 305
EP - 311
JO - European Archives of Psychiatry and Clinical Neuroscience
JF - European Archives of Psychiatry and Clinical Neuroscience
IS - 4
ER -
