Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia

Concetta Crisafulli; Alberto Chiesa; Diana De Ronchi; Changsu Han; Soo Jung Lee; Moon Ho Park; Ashwin A. Patkar; Chi Un Pae; Alessandro Serretti

doi:10.1016/j.neulet.2011.10.074

Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia

Concetta Crisafulli, Alberto Chiesa, Diana De Ronchi, Changsu Han, Soo Jung Lee, Moon Ho Park, Ashwin A. Patkar, Chi Un Pae, Alessandro Serretti

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. One hundred forty five patients with MD, 221 in-patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. No significant association was found with the diagnosis of schizophrenia. We observed an association between rs3813296 genotype and improvement on PANSS negative scores. Our findings provide no evidence for an association between SNPs within GRIA1, GRIA2 and GRIA4 under investigation and schizophrenia susceptibility, although rs3813296 (GRIA2) could be associated with improvement on PANSS negative scores. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.

Original language	English
Pages (from-to)	170-174
Number of pages	5
Journal	Neuroscience Letters
Volume	506
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2011.10.074
Publication status	Published - 2012 Jan 6
Externally published	Yes

Keywords

Antipsychotics
GRIA1
GRIA2
GRIA4
Glutamate receptors
Schizophrenia

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2011.10.074

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title = "Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia",

abstract = "The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. One hundred forty five patients with MD, 221 in-patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. No significant association was found with the diagnosis of schizophrenia. We observed an association between rs3813296 genotype and improvement on PANSS negative scores. Our findings provide no evidence for an association between SNPs within GRIA1, GRIA2 and GRIA4 under investigation and schizophrenia susceptibility, although rs3813296 (GRIA2) could be associated with improvement on PANSS negative scores. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.",

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author = "Concetta Crisafulli and Alberto Chiesa and {De Ronchi}, Diana and Changsu Han and Lee, {Soo Jung} and Park, {Moon Ho} and Patkar, {Ashwin A.} and Pae, {Chi Un} and Alessandro Serretti",

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doi = "10.1016/j.neulet.2011.10.074",

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AU - Crisafulli, Concetta

AU - Chiesa, Alberto

AU - De Ronchi, Diana

AU - Han, Changsu

AU - Lee, Soo Jung

AU - Park, Moon Ho

AU - Patkar, Ashwin A.

AU - Pae, Chi Un

AU - Serretti, Alessandro

PY - 2012/1/6

Y1 - 2012/1/6

N2 - The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. One hundred forty five patients with MD, 221 in-patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. No significant association was found with the diagnosis of schizophrenia. We observed an association between rs3813296 genotype and improvement on PANSS negative scores. Our findings provide no evidence for an association between SNPs within GRIA1, GRIA2 and GRIA4 under investigation and schizophrenia susceptibility, although rs3813296 (GRIA2) could be associated with improvement on PANSS negative scores. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.

AB - The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within GRIA1, GRIA2 and GRIA4 could be associated with schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antipsychotics. One hundred forty five patients with MD, 221 in-patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for 17 SNPs within GRIA1, GRIA2 and GRIA4. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. No significant association was found with the diagnosis of schizophrenia. We observed an association between rs3813296 genotype and improvement on PANSS negative scores. Our findings provide no evidence for an association between SNPs within GRIA1, GRIA2 and GRIA4 under investigation and schizophrenia susceptibility, although rs3813296 (GRIA2) could be associated with improvement on PANSS negative scores. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions.

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Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to antipsychotic treatment in patients with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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