Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in Diabetic Feet

Jae A. Jung, Ki Hyun Yoo, Seung Kyu Han, Ye Na Lee, Seong Ho Jeong, Eun Sang Dhong, Woo Kyung Kim

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


OBJECTIVE: Negative-pressure wound therapy (NPWT) has become a common wound care treatment modality for a variety of wounds. Several previous studies have reported that NPWT increases blood flow in the wound bed. However, NPWT might decrease tissue oxygenation in the wound bed because the foam sponge of NPWT compresses the wound bed under the influence of the applied negative pressure. Adequate tissue oxygenation is an essential consideration during diabetic foot management, and the foot is more sensitive to ischemia than any other region. Furthermore, the issue as to whether NPWT reduces or increases tissue oxygenation in diabetic feet has never been correctly addressed. The aim of this study was to evaluate the influence of NPWT on tissue oxygenation in diabetic feet. PARTICIPANTS: Transcutaneous partial oxygen pressures (TcPo2) were measured to determine tissue oxygenation levels beneath NPWT dressings on 21 feet of 21 diabetic foot ulcer patients. DESIGN: A TcPo2 sensor was fixed at the tarsometatarsal area of contralateral unwounded feet. A suction pressure of-125 mm Hg was applied until TcPo2 reached a steady state. The TcPo2 values for diabetic feet were measured before, during, and after NPWT. MAIN RESULTS: The TcPo2 levels decreased significantly after applying NPWT in all patients. Mean TcPo2 values before, during, and after therapy were 44.6 (SD, 15.2), 6.0 (SD, 7.1), and 40.3 (SD, 16.4) mm Hg (P <.01), respectively. CONCLUSION: These results show that NPWT significantly reduces tissue oxygenation levels in diabetic feet.

Original languageEnglish
Pages (from-to)364-370
Number of pages7
JournalAdvances in Skin and Wound Care
Issue number8
Publication statusPublished - 2016 Aug 1
Externally publishedYes


  • diabetic foot
  • negative-pressure wound therapy
  • tissue oxygenation

ASJC Scopus subject areas

  • Dermatology
  • Advanced and Specialised Nursing


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