Influence of shear stress on erythrocyte aggregation

Jeong Ho Kim, Hoyoon Lee, Byoung Kwon Lee, Sehyun Shin

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Shear stress is known to induce platelet activation and aggregation. The red blood cell (RBC) aggregation test requires the application of shear stress for the cells to disaggregate for initialization. We tested the hypothesis that applying shear stress may activate platelets, which can influence RBC aggregation. The present study used a commercial microchip-based aggregometer (RheoSCan-AnD300) with a rotating stirrer for RBC disaggregation. Whole blood samples were exposed to different magnitudes of shear stress with various shearing times. As the rotational speed was increased up to 2800 rpm, the RBC aggregation index (AI) of the whole blood increased by up to 30 (p < 0.05), whereas that of the platelet-excluded blood samples did not show any apparent alteration. The AI also increased in proportion with the stirring time. The data suggest that high shear stress affects RBC aggregation through shear-induced platelet aggregation.

    Original languageEnglish
    Pages (from-to)165-171
    Number of pages7
    JournalClinical Hemorheology and Microcirculation
    Volume62
    Issue number2
    DOIs
    Publication statusPublished - 2016 Mar 18

    Bibliographical note

    Publisher Copyright:
    © 2016 - IOS Press and the authors. All rights reserved.

    Keywords

    • RBC
    • aggregation
    • platelet aggregation
    • shear stress

    ASJC Scopus subject areas

    • Physiology
    • Hematology
    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

    Fingerprint

    Dive into the research topics of 'Influence of shear stress on erythrocyte aggregation'. Together they form a unique fingerprint.

    Cite this